Scorpion envenomation and inflammation: beyond neurotoxic effects
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2019
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Resumo
Scorpion envenomation results in a wide range of clinical manifestations that are mostly attributed to the ac tivation of the autonomic nervous system by venom toxins. In fact, sympathetic and parasympathetic dis turbances play important roles during poisoning. However, scorpion venom also induces a complex hyperin flammatory state that occurs parallel to systemic inflammatory response syndrome and acute sepsis. After a
scorpion sting, innate immune cells are exposed to the venom molecules, which bind to pattern recognition
receptors and activate pro-inflammatory pathways that contribute toward the promotion of severe symptoms,
such as pulmonary edema, and eventually lead to death. In this review, we highlight studies that pointed out
inflammation as a major pathological facet of scorpion envenomation, so as to provide novel targets to improve
therapeutics for scorpionism.
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Inflammation, Scorpion venom, Eicosanoids, TLRs, VAMPs
Citação
REIS, Mouzarllem Barros et al. Scorpion envenomation and inflammation: beyond neurotoxic effects. Toxicon, Oxford, v. 167, p. 1, 2019. DOI: 10.1016/j.toxicon.2019.06.219. Disponível em: https://www.sciencedirect.com/science/article/pii/S0041010119303940?via%3Dihub. Acesso em: 29 jan. 2025.