Scorpion envenomation and inflammation: beyond neurotoxic effects

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dc.creatorReis, Mouzarllem Barros dos
dc.creatorZoccal, Karina Furlani
dc.creatorGardinassi, Luiz Gustavo Araujo
dc.creatorFaccioli, LĂșcia Helena 
dc.date.accessioned2025-02-04T15:33:28Z
dc.date.available2025-02-04T15:33:28Z
dc.date.issued2019
dc.description.abstractScorpion envenomation results in a wide range of clinical manifestations that are mostly attributed to the ac tivation of the autonomic nervous system by venom toxins. In fact, sympathetic and parasympathetic dis turbances play important roles during poisoning. However, scorpion venom also induces a complex hyperin flammatory state that occurs parallel to systemic inflammatory response syndrome and acute sepsis. After a scorpion sting, innate immune cells are exposed to the venom molecules, which bind to pattern recognition receptors and activate pro-inflammatory pathways that contribute toward the promotion of severe symptoms, such as pulmonary edema, and eventually lead to death. In this review, we highlight studies that pointed out inflammation as a major pathological facet of scorpion envenomation, so as to provide novel targets to improve therapeutics for scorpionism.
dc.identifier.citationREIS, Mouzarllem Barros et al. Scorpion envenomation and inflammation: beyond neurotoxic effects. Toxicon, Oxford, v. 167, p. 1, 2019. DOI: 10.1016/j.toxicon.2019.06.219. DisponĂ­vel em: https://www.sciencedirect.com/science/article/pii/S0041010119303940?via%3Dihub. Acesso em: 29 jan. 2025.
dc.identifier.doi10.1016/j.toxicon.2019.06.219
dc.identifier.issn0041-0101
dc.identifier.issne- 1879-3150
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/26519
dc.language.isoeng
dc.publisher.countryGra-bretanha
dc.publisher.departmentInstituto de Patologia Tropical e SaĂșde PĂșblica - IPTSP (RMG)
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectInflammation
dc.subjectScorpion venom
dc.subjectEicosanoids
dc.subjectTLRs
dc.subjectVAMPs
dc.titleScorpion envenomation and inflammation: beyond neurotoxic effects
dc.typeArtigo

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