A structural perspective of plant antimicrobial peptides

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dc.creatorCampos, Marcelo Lattarulo
dc.creatorLiao, Luciano Morais
dc.creatorAlves, Eliane Santana Fernandes
dc.creatorMigliolo, Ludovico
dc.creatorDias, Simoni Campos
dc.creatorFranco, Octavio Luiz
dc.date.accessioned2024-02-07T10:39:57Z
dc.date.available2024-02-07T10:39:57Z
dc.date.issued2018
dc.description.abstractAmong the numerous strategies plants have developed to fend off enemy attack, antimicrobial peptides (AMPs) stand out as one of the most prominent defensive barriers that grant direct and durable resistance against a wide range of pests and pathogens. These small proteins are characterized by a compact structure and an overall positive charge. AMPs have an ancient origin and widespread occurrence in the plant kingdom but show an unusually high degree of variation in their amino acid sequences. Interestingly, there is a strikingly conserved topology among the plant AMP families, suggesting that the defensive properties of these peptides are not determined by their primary sequences but rather by their tridimensional structure. To explore and expand this idea, we here discuss the role of AMPs for plant defense from a structural perspective. We show how specific structural properties, such as length, charge, hydrophobicity, polar angle and conformation, are essential for plant AMPs to act as a chemical shield that hinders enemy attack. Knowledge on the topology of these peptides is facilitating the isolation, classification and even structural redesign of AMPs, thus allowing scientists to develop new peptides with multiple agronomical and pharmacological potential.
dc.identifier.citationCAMPOS, Marcelo Lattarulo et al. A structural perspective of plant antimicrobial peptides. Biochemical Journal, London, v. 475, p. 3359-3375, 2018. DOI: 10.1042/BCJ20180213. Disponível em: https://portlandpress.com/biochemj/article-abstract/475/21/3359/49903/A-structural-perspective-of-plant-antimicrobial?redirectedFrom=fulltext. Acesso em: 29 jan. 2024.
dc.identifier.doi10.1042/BCJ20180213
dc.identifier.issne- 1470-8728
dc.identifier.issn0264-6021
dc.identifier.urihttps://portlandpress.com/biochemj/article-abstract/475/21/3359/49903/A-structural-perspective-of-plant-antimicrobial?redirectedFrom=fulltext
dc.language.isoeng
dc.publisher.countryGrã-Bretanha
dc.publisher.departmentInstituto de Química - IQ (RMG)
dc.rightsAcesso Restrito
dc.subjectDefense
dc.subjectPeptide topology
dc.subjectPlant immunity
dc.subjectRational design
dc.subjectTridimensional structure
dc.titleA structural perspective of plant antimicrobial peptides
dc.typeArtigo

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