Estudo do efeito do gossipol no sangue de camundongos (mus domesticus domesticus)

Abstract

Twenty thirty day-old male mice weigbing 25 g were divided in two groups: Group 1: oral saline solution (control), and Group 2: oral gossipol acetic-acid at 20 mg/kg. Forty days after treatments and leukocytes were counted through Newbawer counting charnber. leukometry showed 9241 leukocytes/mm3 for the control and 6125 leukocytes/mm3 for the gossipol treated group (significant difference for P=0,05). Erythrometry showed 659600 1mm' and 6399000 erythrocytes/mm3 for control and gossipol treated mice, respectively. It was concluded that gossipol may induce a deleterious effect on the organism defense cells.