Acute oral toxicity of Celtis iguanaea (Jacq.) Sargent leaf extract (Ulmaceae) in rats and mice
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Data
2015
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Resumo
Celtis iguanaea (Jacq.) Sargent is popularly used to treat urinary infections,
kidneys, breast, body aches, rheumatism, asthma, cramps, poor digestion and as a diuretic
medicine. This study aims to determine the acute toxicity of the aqueous leaf extract of Celtis
iguanaea (Jacq.) Sargent in rodents. After the collection processes, identification, drying and
grinding, the lyophilized powder of the leaves produced, by infusion, the aqueous extract and
it was dissolved in saline 0.9%. The administration was made by gavage at a dose of 2000 mg
kg -1 to rats and mice of both genders. The oral toxicity was determined according to the OECD
423 guide. Signs of toxicity were observed for 15 days and classified from 0 to 4 respectively
as missing, rare, mild, moderate and severe. The weight of the animals and the physiological
parameters such as food intake and excrements production were observed. All animal tissue
samples were collected for histological analysis. The extract was included in Type 5 (substance
with LD50 higher than 2000 mg kg -1 and less than 5000 mg kg -1 ), being considered of low toxicity,
but the histopathologycal findings suggested nephrotoxicity and cardiotoxicity. The absolute
weight of the kidneys and the heart of the male rats and mice increased, but there was no
significant raise in the relative weight of the animals’ organs.
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Palavras-chave
Medicinal plants, Acute oral toxicity, Celtis iguanaea, Plantas medicinais, Celtis iguanaea, Toxicidade oral aguda
Citação
GONCALVES, N. Z. et al. Acute oral toxicity of Celtis iguanaea (Jacq.) Sargent leaf extract (Ulmaceae) in rats and mice. Revista Brasileira de Plantas Medicinais, Campinas, v. 17, n. 4, suppl. 3, p. 1118-1124, 2015.