Campomanesia adamantium (Myrtaceae) fruits protect HEPG2cells against carbon tetrachloride-induced toxicity

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dc.creatorFernandes, Thaís de Oliveira Fernandesa
dc.creatorMarcelino, Renato Ivan de Ávila
dc.creatorMoura, Soraia Santana de
dc.creatorOliveira, Gerlon de Almeida Ribeiro
dc.creatorNaves, Maria Margareth Veloso
dc.creatorValadares, Marize Campos
dc.date.accessioned2022-01-26T13:28:32Z
dc.date.available2022-01-26T13:28:32Z
dc.date.issued2015
dc.description.abstractCampomanesia adamantium (Myrtaceae) is an antioxidant compounds-rich Brazilian fruitpopularly known as gabiroba. In view of this, it was evaluated the hepatoprotective effects ofpulp (GPE) or peel/seed (GPSE) hydroalcoholic extracts of gabiroba on injured liver-derivedHepG2 cells by CCl4(4 mM). The results showed the presence of total phenolic in GPSE was(60%) higher when compared to GPE, associated with interesting antioxidant activity usingDPPH•assay. Additionally, HPLC chromatograms and thin layer chromatography of GPE andGPSE showed the presence of flavonoids. Pretreatment of HepG2 cells with GPE or GPSE(both at 800–1000 g/mL) significantly (p < 0.0001) protected against cytotoxicity inducedby CCl4.Additionally, the cells treated with both extracts (both at 1000 g/mL) showednormal morphology (general and nuclear) contrasting with apoptotic characteristics in thecells only exposed to CCl4. In these experiments, GPSE also was more effective than GPE. Inaddition, CCl4induced a marked increase in AST (p < 0.05) and ALT (p < 0.0001) levels, whileGPE or GPSE significantly (p < 0.0001) reduced these levels, reaching values found in thecontrol group. In conclusion, the results suggest that gabiroba fruits exert hepatoprotectiveeffects on HepG2 cells against the CCl4-induced toxicity, probably, at least in part, associatedwith the presence of antioxidant compounds, especially flavonoids.pt_BR
dc.identifier.citationFERNANDES, Thaís de Oliveira et al. Campomanesia adamantium (Myrtaceae) fruits protect HEPG2 cells against carbon tetrachloride-induced toxicity. Toxicology Reports, Ireland, v. 2, p. 184-193, 2015.pt_BR
dc.identifier.doi10.1016/j.toxrep.2014.11.018
dc.identifier.issn2214-7500
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/20220
dc.language.isoengpt_BR
dc.publisher.countryOutrospt_BR
dc.publisher.departmentFaculdade de Nutrição - FANUT (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCampomanesia adamantium (Myrtaceae)pt_BR
dc.subjectHepatoprotectionHepG2 cellsapt_BR
dc.subjectCarbon tetrachloridept_BR
dc.subjectFlavonoidspt_BR
dc.subjectHepG2 cellspt_BR
dc.titleCampomanesia adamantium (Myrtaceae) fruits protect HEPG2cells against carbon tetrachloride-induced toxicitypt_BR
dc.typeArtigopt_BR

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