A selanylimidazopyridine (3-SePh-IP) reverses the prodepressant- and anxiogenic-like effects of a high-fat/high-fructose diet in mice

Veloso, Izolene Corrêa; Delanogare, Eslen; Machado, Adriano Emanuel; Braga, Sara Pereira; Rosa, Giovana Karoline; Bem, Andreza Fabro de; Khan, Jamal Rafique; Saba, Sumbal; Trindade, Roberth Nascimento da; Galetto, Fábio Zazyki; Moreira, Eduardo Luiz Gasnhar

A selanylimidazopyridine (3-SePh-IP) reverses the prodepressant- and anxiogenic-like effects of a high-fat/high-fructose diet in mice

Data

2021-03-02

Autores

Veloso, Izolene Corrêa

Delanogare, Eslen

Machado, Adriano Emanuel

Braga, Sara Pereira

Rosa, Giovana Karoline

Bem, Andreza Fabro de

Khan, Jamal Rafique

Saba, Sumbal

Trindade, Roberth Nascimento da

Galetto, Fábio Zazyki

Resumo

While chronic feeding with high-fat or high-sugar diets is known related to obesity and type 2 diabetes, later data have indicated that it is also related to depression and anxiety appearance. In this regard, multi-target drugs raise considerable interest as promising therapeutic solutions to complex diseases. Considering the pharmacological effects of the imidazopyridine-derivative moiety imidazo[1,2-a]pyridine and the organoselenium molecules, the combination of both could be a feasible strategy to develop efficient drugs to handle obesity and related comorbidities, for example dyslipidemia and mood disorders. Methods The antidepressant- and anxiolytic-like properties of a selanylimidazopyridine compound, 2-Phenyl-3-(phenylselanyl)imidazo[1,2-a]pyridine (3-SePh-IP), were evaluated on high-fat/high-fructose diet (HFFD)-fed female Swiss mice. Key findings Our results showed that a short-term HFFD (16 days) could promote a significant body weight gain, hypercholesterolemia, glucose intolerance, and anxiety- and depressive-like behaviour in mice. Concomitant treatment with 3-SePh-IP (10 mg/kg; i.p.) attenuated the HFFD-induced increase in cholesterol levels and blunted the anxiety- and depressive-like behaviour in mice. Conclusions 3-SePh-IP holds multimodal pharmacological properties, which provide a rationale for further studies, for example to assess the underlying mechanisms linked to its anxiolytic- and antidepressive-like activities

Palavras-chave

Imidazopyridine, Selenium, Behavioural, besity

Citação

VELOSO, Izolene Corrêa et al. A selanylimidazopyridine (3-SePh-IP) reverses the prodepressant- and anxiogenic-like effects of a high-fat/high-fructose diet in mice. Journal of Pharmacy and Pharmacology, [s. l.], v. 73, n. 5, p. 673-681, 2021. DOI: 10.1093/jpp/rgaa070. A Disponível em: https://academic.oup.com/jpp/article/73/5/673/6156912. Acesso em: 31 jul. 2024.