Supplementing alpha-tocopherol (vitamin E) and vitamin D3 in high fat diet decrease IL-6 production in murine epididymal adipose tissue and 3T3-L1 adipocytes following LPS stimulation

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dc.creatorLira, Fábio Santos de
dc.creatorSouza, José Carlos Rosa Pires de
dc.creatorCunha, Claudio Alexandre
dc.creatorRibeiro, Eliane Beraldi
dc.creatorNascimento, Claudia Maria da Penha Oller do
dc.creatorOyama, Lila Missae
dc.creatorMota, João Felipe
dc.date.accessioned2019-02-12T11:11:44Z
dc.date.available2019-02-12T11:11:44Z
dc.date.issued2011
dc.description.abstractBackground: It is well known that high fat diets (HFDs) induce obesity and an increase in proinflammatory adipokines. Interleukin-6 (IL-6) is considered the major inflammatory mediator in obesity. Obesity is associated with a vitamin deficiency, especially of vitamins E and D3. We examined the effects of vitamin D3 and vitamin E supplementation on levels of IL-6 and IL-10 (as a marker of anti-inflammatory cytokines since, a balance between pro- and anti-inflammatory cytokines is maintained) protein expression in adipose tissue of mice provided with an HFD. Additionally, we measured the effects of vitamin E and vitamin D3 treatment on LPS-stimulated 3T3-L1 adipocytes IL-6 and IL-10 secretion. Results: IL-6 protein levels and the IL-6/IL-10 ratio were decreased in epididymal white adipose tissue in groups receiving vitamins E and D3 supplementation compared to the HFD group. A 24-hour treatment of vitamin D3 and vitamin E significantly reduced the IL-6 levels in the adipocytes culture medium without affecting IL-10 levels. Conclusions: Vitamin D3 and vitamin E supplementation in an HFD had an anti-inflammatory effect by decreasing IL-6 production in epididymal adipose tissue in mice and in 3T3-L1 adipocytes stimulated with LPS. Our results suggest that vitamin E and D3 supplementation can be used as an adjunctive therapy to reduce the proinflammatory cytokines present in obese patients.pt_BR
dc.identifier.citationLIRA, Fábio S. et al. Supplementing alpha-tocopherol (vitamin E) and vitamin D3 in high fat diet decrease IL-6 production in murine epididymal adipose tissue and 3T3-L1 adipocytes following LPS stimulation. Lipids in Health and Disease, London, v. 10, n. 37, p. 1-5, 2011.pt_BR
dc.identifier.doi10.1186/1476-511X-10-37
dc.identifier.issne- 1476-511X
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/17048
dc.language.isoengpt_BR
dc.publisher.countryGra-bretanhapt_BR
dc.publisher.departmentFaculdade de Nutrição - FANUT (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.titleSupplementing alpha-tocopherol (vitamin E) and vitamin D3 in high fat diet decrease IL-6 production in murine epididymal adipose tissue and 3T3-L1 adipocytes following LPS stimulationpt_BR
dc.typeArtigopt_BR

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