Synthesis of triazole derivatives of levoglucosenone as promising anticancer agents: effective exploration of the chemical space through retro-aza-Michael//aza-Michael isomerizations

Resumo

The design and synthesis of biomass-derived triazoles and the in vitro evaluation as potential anticancer agents are described. The discovery of base-catalyzed retro-aza-Michael//aza-Michael isomerizations allowed the exploration of the chemical space by affording novel types of triazoles, difficult to obtain otherwise. Following this strategy, 2,4-disubstituted 1,2,3-triazoles could be efficiently obtained from the corresponding 1,4-disubstituted analogues.

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Citação

YI-HSUAN, Tsai et al. Synthesis of triazole derivatives of levoglucosenone as promising anticancer agents: effective exploration of the chemical space through retro-aza-Michael//aza-Michael isomerizations. The Journal of Organic Chemistry, Washington, v. 83, n. 7, p. 3516-3528, 2018. DOI: 10.1021/acs.joc.7b03141. Disponível em: https://pubs.acs.org/doi/10.1021/acs.joc.7b03141. Acesso em: 28 nov. 2023.