Antigenotoxic, and anticytotoxic activities of an ethanolic extract of Lafoensia pacari (Lythraceae) stem bark in bacteria and mice
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Data
2013
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Resumo
Lafoensia pacari (Lythraceae), popularly known in
Brazil as “pacari”, is a small tree native to the Cerrado that is used in folk
medicine to treat cancer and as an anti-inflammatory and cicatrizing agent.
We evaluated the genotoxic, cytotoxic, antigenotoxic, and anticytotoxic
activities of an ethanol extract of L. pacari stem bark (EESB) using the
Ames test and the mouse bone marrow micronucleus test. In the Ames
test, EESB did not significantly increase the number of His + revertants
in Salmonella typhimurium tester strains TA98 and TA100 at all doses,
demonstrating lack of mutagenicity. Only the highest dose of EESB
significantly increased the micronucleated polychromatic erythrocyte
frequency in the micronucleus test, indicating mild genotoxicity.
EESB produced a mutagenic index lower than the negative control in
the Ames test. In the micronucleus test, at all doses, EESB caused a
significant decrease in the polychromatic/normochromatic erythrocyte
ratio (PCE/NCE) at 24 h compared with the negative control. EESB
co-administered together with the respective positive control caused a significant decrease in the number of His + revertant colonies in the
Ames test and in the frequency of micronucleated polychromatic
erythrocytes in the micronucleus test, demonstrating a DNA protector
effect. EESB co-administered with mitomycin C significantly increased
the PCE/NCE ratio at all doses, showing an anticytotoxic effect. We
conclude that EESB has antigenotoxic and anticytotoxic properties.
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Palavras-chave
Lafoensia pacari, Anticytotoxicity, Pacari, Mice, Antigenotoxicity, Bacteria
Citação
LIMA, D. C.; SILVA, C. R.; SAMPAIO, B. L.; PAULA, J. R. de; L., Chen-Chen. Antigenotoxic, and anticytotoxic activities of an ethanolic extract of Lafoensia pacari (Lythraceae) stem bark in bacteria and mice. Genetics and Molecular Research, Ribeirão Preto, v. 12, n. 3, p. 3887-3896, 2013.