Temporal and spatial changes in cerebral blood flow in neuropsychiatric systemic lupus erythematosus: a subtraction brain spect study

Página do item simplificado
dc.creatorTrevisan, Ana Carolina
dc.creatorSantos, Leonardo Alexandre
dc.creatorAssad, Rodrigo Luppino
dc.creatorItikawa, Emerson Nobuyuki
dc.creatorPitella, Felipe Arriva
dc.creatorKato, Mery
dc.creatorSilvah, José Henrique da
dc.creatorSantos, Antonio Carlos dos
dc.creatorLouzada Junior, Paulo
dc.creatorAna, Lauro Wichert
dc.date.accessioned2023-04-20T14:27:34Z
dc.date.available2023-04-20T14:27:34Z
dc.date.issued2021
dc.description.abstractThis study was addressed to evaluate the temporal and spatial changes in regional cerebral blood flow (rCBF) of patients with neuropsychiatric systemic lupus erythematosus (NPSLE). Our objective was to correlate the subtracted SPECT coregistered to MRI features (SISCOM) with demographic, clinical and laboratory findings to shed light upon the pathophysiological evolution of the NPSLE. Twenty-six NPSLE patients with MRI and pre- and post-treatment brain SPECT with [99mTc]Tc-ECD. SISCOM features were categorized as improvement, worsening, activation and/or deactivation of rCBF findings. Patients mean age of 43.19 years and 65.38% white were evaluated. The patients mean age at onset of SLE was 26.05 and 42.29 for NPSLE. The mean time between the onset of SLE and first NPSLE symptoms was 05.57 years. The disease has already been initiated as NPSLE in 4 patients. The SLEDAI average score was 31.69 and the SLICC/ACR-DI score was 06.96. The patients underwent an average of 09.23 cyclophosphamide. The SISCOM findings showed functional and pathological states on different brain regions. The rCBF changes were not associated with index scores. There was, however, a trend towards an association between lower SLEDAI scores with improvement and higher SLEDAI with worsening in SISCOM, Also a trend of association between lower SLICC score with improvement, and higher SLICC with worsening. The female gender was predictive of activation and worsening, separately, and deactivation and worsening in a set. Non-white patients were predictive of worsening. The seizure was predictive of deactivation separately, and deactivation and worsening in a set. Finally, normal C3 was a predictor of improvement. The present study showed dynamic brain changes in NPSLE patients. SISCOM technique showed improved rCBF in some brain areas, and worsening, activation and deactivation in others. There were associations between rCBF changes and gender, skin colour and complement C3 and association trends with SLEDAI and SLICC scores.pt_BR
dc.identifier.citationTREVISAN, Ana Carolina et al. Temporal and spatial changes in cerebral blood flow in neuropsychiatric systemic lupus erythematosus: a subtraction brain spect study. European Journal of Hybrid Imaging, London, v. 5, n. 1, p. 1-13, 2021. DOI: 10.1186/s41824-021-00112-3. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34734310/. Acesso em: 19 abr. 2023.pt_BR
dc.identifier.doi10.1186/s41824-021-00112-3.
dc.identifier.issne- 2510-3636
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/22384
dc.language.isoengpt_BR
dc.publisher.countryGra-bretanhapt_BR
dc.publisher.departmentInstituto de Física - IF (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSystemic lupus erythematosuspt_BR
dc.subjectSISCOMpt_BR
dc.subjectNeuropsychiatric formpt_BR
dc.subjectBrain SPECTpt_BR
dc.titleTemporal and spatial changes in cerebral blood flow in neuropsychiatric systemic lupus erythematosus: a subtraction brain spect studypt_BR
dc.typeArtigopt_BR

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
Artigo - Ana Carolina Trevisan - 2021.pdf
Tamanho:
843.03 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Baixar

Coleções

IF - Artigos publicados em periódicos