Molecular characterization of hepatitis A virus isolates from Goiânia, Goiás, Brazil

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dc.creatorFiaccadori, Fabíola Souza
dc.creatorPereira, Maristela
dc.creatorCoelho, Alexandre Siqueira Guedes
dc.creatorBorges, Ana Maria Tavares
dc.creatorRocha, Juliana Alves Parente
dc.creatorSoares, Célia Maria de Almeida
dc.creatorCardoso, Divina das Dôres de Paula
dc.date.accessioned2018-07-05T11:22:03Z
dc.date.available2018-07-05T11:22:03Z
dc.date.issued2008-12
dc.description.abstractHepatitis A virus (HAV) infection is a public health problem worldwide and the virus has been classified into six genotypes. In Brazil, the only genotype that has been found is genotype I, predominately from subgenotype IA. Here, the HAV genotypes were analyzed of 18 isolates circulating between 1996-2001 in Goiânia, state of Goiás, Brazil. Viral RNA was extracted from 18 serum samples and amplified (RT-PCR/nested-PCR), followed by the genomic sequencing of the VP1/2A junction region of the HAV genome. Sequences of 168 nucleotides were compared and analyzed using the BLAST N, Clustal X and PAUP v. 4.10b programs. All samples were classified as genotype I, with 10 belonging to subgenotype IA and eight to subgenotype IB. The subgenotype IA isolates showed greater diversity than the subgenotype IB isolates at the nucleotide level. Elevated identity values were found between isolates ob- tained in this study and those from other regions of the world, including Brazil, highlighting the high conservation among different isolates of this virus. However, changes in the HAV subgenotype circulation could also be observed during the evaluated period.pt_BR
dc.identifier.citationFIACCADORI, Fabíola Souza; PEREIRA, Maristela ; COELHO, Alexandre Siqueira Guedes; BORGES, Ana Maria Tavares; PARENTE, Juliana Alves; SOARES, Célia Maria de Almeida; CARDOSO, Divina das Dores de Paula. Molecular characterization of hepatitis A virus isolates from Goiânia, Goiás, Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 8, p. 831-835, Dec. 2008.pt_BR
dc.identifier.doi10.1590/S0074-02762008000800015
dc.identifier.issn0074-0276
dc.identifier.issn1678-8060
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/15346
dc.language.isoengpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectAcute hepatitispt_BR
dc.subjectSubgenotype IBpt_BR
dc.subjectNucleotide sequencingpt_BR
dc.subjectSubgenotype IApt_BR
dc.titleMolecular characterization of hepatitis A virus isolates from Goiânia, Goiás, Brazilpt_BR
dc.typeArtigopt_BR

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