Determinação de designer drugs em saliva por paper spray mass spectrometry
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2019-06-27
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Determination of
two drugs of abuse in saliva has been performed by Paper Spray Ionization Mass Spectrometry (PSI-MS) using a Molecularly
Imprinted Polymer (MIP) coated paper as substrate. The method has been optimized for quantification of 3,4-methylenedioxyN-methylamphetamine (MDMA) and methamphetamine, 3,4-methylenedioxyamphetamine (MDA) from synthetic saliva samples.
Rapid analysis (~ 1 min) of designer drugs in saliva is demonstrated using MIP-PSI-MS. Both precursor ions of MDMA and MDA
were confirmed by tandem mass spectrometry (MS/MS) experiments by elucidating the fragmentation patterns formed via collisioninduced dissociation (CID). The MIP-PSI-MS method showed greater selectivity for MDMA and MDA in comparison with other
analytes. Signal intensity ratios of the most important transitions for MDMA (194 → 163) and MDA (180 → 163) were found linear
(R > 0,99) in the range 25-500 µg L-¹. The LOD and LOQ for MDMA were 1.11 µg L-¹ and 18.73 µg L-¹, respectively, and for MDA
were 3.42 µg L-¹ and 21.66 µg L-¹, respectively. The precision and accuracy values were determined below 4%, and the recoveries
about 100%, without pre-concentration/enrichment or separation steps. The MIP-PSI-MS method displays the potential for rapid
screening for selective quantitative determination of illicit drugs in saliva samples.
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Mass spectrometry (MS), Paper spray ionization, Molecularly imprinted polymer (MIP), MDMA, MDA
Citação
MACIEL, Lanaia Ítala L.; CARVALHO, Thays C.; PEREIRA, Igor; VAZ, Boniek G. Determinação de designer drugs em saliva por paper spray mass spectrometry. Química Nova, São Paulo, v. 42, n. 6, p. 676-682, 2019. DOI: 10.21577/0100-4042.20170379. Disponível em:
https://s3.sa-east-1.amazonaws.com/static.sites.sbq.org.br/quimicanova.sbq.org.br/pdf/NT20180514.pdf. Acesso em: 21 jun. 2023.