Biomarkers and their possible functions in the intestinal microenvironment of chagasic megacolon: an overview of the (neuro)inflammatory process
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2021
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The association between inflammatory processes and intestinal neuronal destruction during the progression of Chagasic
megacolon is well established. However, many other components play essential roles, both in the long-term progression and
control of the clinical status of patients infected with Trypanosoma cruzi. Components such as neuronal subpopulations, enteric
glial cells, mast cells and their proteases, and homeostasis-related proteins from several organic systems (serotonin and
galectins) are differentially involved in the progression of Chagasic megacolon. This review is aimed at revealing the
characteristics of the intestinal microenvironment found in Chagasic megacolon by using different types of already used
biomarkers. Information regarding these components may provide new therapeutic alternatives and improve the understanding
of the association between T. cruzi infection and immune, endocrine, and neurological system changes.
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CARMO NETO, José Rodrigues do et al. Biomarkers and their possible functions in the intestinal microenvironment of chagasic megacolon: an overview of the (neuro)inflammatory process. Journal of Immunology Research, Cairo, v. 2021, e668739, 2021. DOI: 10.1155/2021/6668739. Disponível em: https://onlinelibrary.wiley.com/doi/10.1155/2021/6668739. Acesso em: 5 fev. 2025.