Biomarkers and their possible functions in the intestinal microenvironment of chagasic megacolon: an overview of the (neuro)inflammatory process

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dc.creatorCarmo Neto, José Rodrigues do
dc.creatorBraga, Yarlla Loyane Lira
dc.creatorCosta, Arthur Wilson Florencio da
dc.creatorLucio, Fernanda Hélia
dc.creatorNascimento, Thais Cardoso do
dc.creatorReis, Marlene Antonia dos
dc.creatorCeles, Mara Rúbia Nunes
dc.creatorOliveira, Flávia Aparecida de
dc.creatorSilva, Juliana Reis Machado e
dc.creatorSilva, Marcos Vinícius da
dc.date.accessioned2025-02-10T12:50:52Z
dc.date.available2025-02-10T12:50:52Z
dc.date.issued2021
dc.description.abstractThe association between inflammatory processes and intestinal neuronal destruction during the progression of Chagasic megacolon is well established. However, many other components play essential roles, both in the long-term progression and control of the clinical status of patients infected with Trypanosoma cruzi. Components such as neuronal subpopulations, enteric glial cells, mast cells and their proteases, and homeostasis-related proteins from several organic systems (serotonin and galectins) are differentially involved in the progression of Chagasic megacolon. This review is aimed at revealing the characteristics of the intestinal microenvironment found in Chagasic megacolon by using different types of already used biomarkers. Information regarding these components may provide new therapeutic alternatives and improve the understanding of the association between T. cruzi infection and immune, endocrine, and neurological system changes.
dc.identifier.citationCARMO NETO, José Rodrigues do et al. Biomarkers and their possible functions in the intestinal microenvironment of chagasic megacolon: an overview of the (neuro)inflammatory process. Journal of Immunology Research, Cairo, v. 2021, e668739, 2021. DOI: 10.1155/2021/6668739. Disponível em: https://onlinelibrary.wiley.com/doi/10.1155/2021/6668739. Acesso em: 5 fev. 2025.
dc.identifier.doi10.1155/2021/6668739
dc.identifier.issne- 2314-7156
dc.identifier.issn2314-8861
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/26627
dc.language.isoeng
dc.publisher.countryOutros
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RMG)
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleBiomarkers and their possible functions in the intestinal microenvironment of chagasic megacolon: an overview of the (neuro)inflammatory process
dc.typeArtigo

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