2-(4-iodo-2,5-dimetoxifenil)-N-[(2-metoxifenil)metil]etamina ou 25I-NBOMe: caracterização química de uma designer drug

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dc.creatorSantos, Pâmella Ferraz dos
dc.creatorSouza, Lindamara Maria de
dc.creatorMerlo, Bianca Bortolini
dc.creatorCosta, Helber Barcellos da
dc.creatorTose, Lilian Valadares
dc.creatorSantos, Heloa
dc.creatorCosta, Gabriela Vanini
dc.creatorMachado, Leandro Fernandes
dc.creatorOrtiz, Rafael Scorsatto
dc.creatorLimberger, Renata Pereira
dc.creatorVaz, Boniek Gontijo
dc.creatorRomão, Wanderson
dc.date.accessioned2023-07-03T15:27:13Z
dc.date.available2023-07-03T15:27:13Z
dc.date.issued2016
dc.description.abstractDrug trafficking and the introduction of new drugs onto the illicit market are one of the main challenges of the forensic community. In this study, the chemical profile of a new designer drug, 2-(4-iodine-2,5- dimethoxyphenyl)-n-[(2-methoxyphenyl)methyl]etamine or 25I-NBOMe was explored using thin layer chromatography (TLC), ultraviolet-visible spectrophotometry (UV-Vis), attenuated total reflection with Fourier transform infrared spectroscopy(ATRFTIR), gas chromatography mass spectrometry (GC-MS) and electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI-FT-ICR MS). First, the TLC technique was effective for identifying spots related to 25C-, 25B- and 25I-NBOMe compounds, all with the same retention factor, Rf ≈ 0.50. No spot was detected for 2,5-dimethoxy-4-bromoamphetamine, 2,5-Dimethoxy-4-chloroamphetamine or lysergic acid diethylamide compounds. ATR-FTIR preserved the physical-chemical properties of the material, whereas GC-MS and ESI-MS showed better analytical selectivity. ESI(+)FT-ICR MS was used to identify the exact mass (m/z 428.1706 for the [M + H]+ ion), molecular formula (M = C18H22INO3), degree of unsaturation (DBE = 8) and the chemical structure (from collision induced dissociation, CID, experiments) of the 25I-NBOMe compound. Furthermore, the ATR-FTIR and CID results suggested the presence of isomers, where a second structure is proposed as an isomer of the 25I-NBOMe molecule.pt_BR
dc.identifier.citationSANTOS, Pâmella F. dos et al. 2-(4-iodo-2,5-dimetoxifenil)-N-[(2-metoxifenil)metil]etamina ou 25I-NBOMe: caracterização química de uma designer drug. Química Nova, São Paulo, v. 39, n. 2, p. 229-237, 2016. DOI: 10.5935/0100-4042.20150178. Disponível em: https://quimicanova.sbq.org.br/detalhe_artigo.asp?id=6352. Acesso em: 21 jun. 2023.pt_BR
dc.identifier.doi10.5935/0100-4042.20150178
dc.identifier.issne- 1678-7064
dc.identifier.issn0100-4042
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/22871
dc.language.isoporpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Química - IQ (RMG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectDesigner drugspt_BR
dc.subject25I-NBOMept_BR
dc.subjectCCDpt_BR
dc.subjectATR-FTIRpt_BR
dc.subjectGC-MSpt_BR
dc.subjectESI(+)-FT-ICR MSpt_BR
dc.title2-(4-iodo-2,5-dimetoxifenil)-N-[(2-metoxifenil)metil]etamina ou 25I-NBOMe: caracterização química de uma designer drugpt_BR
dc.title.alternative2-(4-iodine-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]etamine or 25I-NBOMe: chemical chracterization of a designer drugpt_BR
dc.typeArtigopt_BR

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