Gut microbiota, probiotics and diabetes

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dc.creatorGomes, Aline Corado
dc.creatorBueno, Allain Amador
dc.creatorSouza, Rávila Graziany Machado de
dc.creatorMota, João Felipe
dc.date.accessioned2019-02-12T11:07:39Z
dc.date.available2019-02-12T11:07:39Z
dc.date.issued2014
dc.description.abstractDiabetes is a condition of multifactorial origin, involving several molecular mechanisms related to the intestinal microbiota for its development. In type 2 diabetes, receptor activation and recognition by microorganisms from the intestinal lumen may trigger inflammatory responses, inducing the phosphorylation of serine residues in insulin receptor substrate-1, reducing insulin sensitivity. In type 1 diabetes, the lowered expression of adhesion proteins within the intestinal epithelium favours a greater immune response that may result in destruction of pancreatic β cells by CD8+ T-lymphocytes, and increased expression of interleukin-17, related to autoimmunity. Research in animal models and humans has hypothesized whether the administration of probiotics may improve the prognosis of diabetes through modulation of gut microbiota. We have shown in this review that a large body of evidence suggests probiotics reduce the inflammatory response and oxidative stress, as well as increase the expression of adhesion proteins within the intestinal epithelium, reducing intestinal permeability. Such effects increase insulin sensitivity and reduce autoimmune response. However, further investigations are required to clarify whether the administration of probiotics can be efficiently used for the prevention and management of diabetes.pt_BR
dc.identifier.citationGOMES, Aline Corado; BUENO, Allain Amador; SOUZA, Rávila Graziany Machado de; MOTA, João Felipe. Gut microbiota, probiotics and diabetes. Nutrition Journal, London, v. 13, n. 60, p. 1-13, 2014.pt_BR
dc.identifier.doi10.1186/1475-2891-13-60
dc.identifier.issne- 1475-2891
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/17046
dc.language.isoengpt_BR
dc.publisher.countryGra-bretanhapt_BR
dc.publisher.departmentFaculdade de Nutrição - FANUT (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectProbioticspt_BR
dc.subjectInsulin resistancept_BR
dc.subjectDiabetes mellituspt_BR
dc.subjectInflammationpt_BR
dc.subjectGut microbiotapt_BR
dc.titleGut microbiota, probiotics and diabetespt_BR
dc.typeArtigopt_BR

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