Desenvolvimento e validação de método analítico espectrofotométrico para doseamento de furosemida matéria-prima

Abstract

The furosemide is a drug that acts as diuretic been used to treat arterial hypertension. Among the methods used for their determination, there is the possibility of quantification of furosemide by spectrophotometrics methods, for presenting good sensitivity and have more affordable cost. This study aimed to develop and validate an analytical methodology for determination of this drug in raw material, using ultraviolet spectrophotometry. The method employed proved to be simple, rapid, specific, linear, accurate, precise and robust to run in a routine of a laboratory of quality control, being an alternative to procedures used. By applying the method developed in this study for the analysis of a oral solution of furosemide it was noted the need and importance of validating the analytical protocol in accordance with the formulation produced..