Echocardiographic parameters and survival in chagas heart disease with severe systolic dysfunction

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dc.creatorFrota, Daniela do Carmo Rassi
dc.creatorVieira, Marcelo Luiz Campos
dc.creatorArruda, Ana Lúcia Martins
dc.creatorHotta, Viviane Tiemi
dc.creatorFurtado, Rogério Gomes
dc.creatorRassi, Danilo Teixeira
dc.creatorRassi, Salvador
dc.date.accessioned2019-11-22T13:37:13Z
dc.date.available2019-11-22T13:37:13Z
dc.date.issued2014
dc.description.abstractBackground: Echocardiography provides important information on the cardiac evaluation of patients with heart failure. The identification of echocardiographic parameters in severe Chagas heart disease would help implement treatment and assess prognosis. Objective: To correlate echocardiographic parameters with the endpoint cardiovascular mortality in patients with ejection fraction < 35%. Methods: Study with retrospective analysis of pre-specified echocardiographic parameters prospectively collected from 60 patients included in the Multicenter Randomized Trial of Cell Therapy in Patients with Heart Diseases (Estudo Multicêntrico Randomizado de Terapia Celular em Cardiopatias) – Chagas heart disease arm. The following parameters were collected: left ventricular systolic and diastolic diameters and volumes; ejection fraction; left atrial diameter; left atrial volume; indexed left atrial volume; systolic pulmonary artery pressure; integral of the aortic flow velocity; myocardial performance index; rate of increase of left ventricular pressure; isovolumic relaxation time; E, A, Em, Am and Sm wave velocities; E wave deceleration time; E/A and E/Em ratios; and mitral regurgitation. Results: In the mean 24.18-month follow-up, 27 patients died. The mean ejection fraction was 26.6 ± 5.34%. In the multivariate analysis, the parameters ejection fraction (HR = 1.114; p = 0.3704), indexed left atrial volume (HR = 1.033; p < 0.0001) and E/Em ratio (HR = 0.95; p = 0.1261) were excluded. The indexed left atrial volume was an independent predictor in relation to the endpoint, and values > 70.71 mL/m2 were associated with a significant increase in mortality (log rank p < 0.0001). Conclusion: The indexed left atrial volume was the only independent predictor of mortality in this population of Chagasic patients with severe systolic dysfunction.pt_BR
dc.identifier.citationRASSI, Daniela do Carmo et al. Echocardiographic parameters and survival in chagas heart disease with severe systolic dysfunction. Arquivos Brasileiros de Cardiologia, Rio de Janeiro, v. 102, n. 3, p. 242-252, 2014.pt_BR
dc.identifier.doi10.5935/abc.20140003
dc.identifier.issn 0066-782X
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/18367
dc.language.isoengpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFaculdade de Medicina - FM (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectEchocardiography /diagnosispt_BR
dc.subjectChagas diseasept_BR
dc.subjectSurvivorship (public health)pt_BR
dc.subjectChagas cardiomyopathypt_BR
dc.titleEchocardiographic parameters and survival in chagas heart disease with severe systolic dysfunctionpt_BR
dc.typeArtigopt_BR

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