Evaluation of the effects of SPONDIAS MOMBIN extract as an alternative antimicrobial drug
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Data
2023-04-17
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Universidade Federal de Goiás
Resumo
The extract of Spondias mombin has constituents which may improve psychiatric disorders, in
addition to having antiviral, antifungal, and antimicrobial activity. But despite having several
benefits, it is necessary to assess whether the extract may interfere with cell metabolism so
furthermore its microbicide potential can be explored. Fifteen Wistar rats were used, divided
into four groups (control group; control with extract; hyperlipidemic diet; hyperlipidemic diet
and extract). For 12 weeks, the animals were weighed and their blood glucose was assessed.
Afterwards, they were euthanized, and the biological material was collected. The evaluation
confirmed the efficacy of the extract of S. mombin against cell metabolism of rats, without
negatively altering cell viability; the group of rats with an hyperlipidemic diet showed an
increase in body weight; however, in the individual assessment of the organs, there were no
significant changes. The glycemic index, liver parameters, lipids, and mineral ions did not
show changes. Furthermore, the antimicrobial potential of S. mombin extract was observed
against Staphylococcus aureus ATCC 29213 and Staphylococcus aureus BLACC. The results
suggest that S. mombin extract did not interfere with cell viability, did not show cytotoxicity to
cells that were exposed to it, nor did it interfere with the metabolism, organs, and biochemical
indices of rats with a standard or hyperlipidemic diet. Considering such characteristics and the
potential activities observed in this present study, additional evaluation should be conducted to
further assess the role of S. mombin extract as a source of new alternative antimicrobial drug as
well as its possible beneficial activity to the cardiovascular system.
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Spondias mombin, Hyperlipidemic diet, Antimicrobial inhibition, Obesity, Staphylococcus aureus
Citação
TAIA, Thais Aratak Marques et al. Evaluation of the effects of SPONDIAS MOMBIN extract as an alternative antimicrobial drug. Revista de Patologia Tropical , Goiânia, v. 52, n. 1, p. 37-49, jan./mar. 2023. DOI: 10.5216/rpt.v52i1.73022. Disponível em: https://revistas.ufg.br/iptsp/article/view/73022/39687. Acesso em: 27 dez. 2023.