Evaluation of the effects of SPONDIAS MOMBIN extract as an alternative antimicrobial drug

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dc.creatorTaia, Thais Aratak Marques
dc.creatorPeres, Marcos Felipe Vilela
dc.creatorOliveira, Igor Mendes Moreira de
dc.creatorTeófilo, Monatha Nayara Guimarães
dc.creatorStoko, Natália Correia
dc.creatorAlves, Suzana Ferreira
dc.creatorBlanch, Graziela Torres
dc.creatorCosta, Sérgio Henrique Nascente
dc.creatorBorges, Leonardo Luiz
dc.creatorCardoso, Alessandra Marques
dc.creatorOliveira, Milton Adriano Pelli de
dc.date.accessioned2024-02-06T19:23:16Z
dc.date.available2024-02-06T19:23:16Z
dc.date.issued2023-04-17
dc.description.abstractThe extract of Spondias mombin has constituents which may improve psychiatric disorders, in addition to having antiviral, antifungal, and antimicrobial activity. But despite having several benefits, it is necessary to assess whether the extract may interfere with cell metabolism so furthermore its microbicide potential can be explored. Fifteen Wistar rats were used, divided into four groups (control group; control with extract; hyperlipidemic diet; hyperlipidemic diet and extract). For 12 weeks, the animals were weighed and their blood glucose was assessed. Afterwards, they were euthanized, and the biological material was collected. The evaluation confirmed the efficacy of the extract of S. mombin against cell metabolism of rats, without negatively altering cell viability; the group of rats with an hyperlipidemic diet showed an increase in body weight; however, in the individual assessment of the organs, there were no significant changes. The glycemic index, liver parameters, lipids, and mineral ions did not show changes. Furthermore, the antimicrobial potential of S. mombin extract was observed against Staphylococcus aureus ATCC 29213 and Staphylococcus aureus BLACC. The results suggest that S. mombin extract did not interfere with cell viability, did not show cytotoxicity to cells that were exposed to it, nor did it interfere with the metabolism, organs, and biochemical indices of rats with a standard or hyperlipidemic diet. Considering such characteristics and the potential activities observed in this present study, additional evaluation should be conducted to further assess the role of S. mombin extract as a source of new alternative antimicrobial drug as well as its possible beneficial activity to the cardiovascular system.
dc.identifier.citationTAIA, Thais Aratak Marques et al. Evaluation of the effects of SPONDIAS MOMBIN extract as an alternative antimicrobial drug. Revista de Patologia Tropical , Goiânia, v. 52, n. 1, p. 37-49, jan./mar. 2023. DOI: 10.5216/rpt.v52i1.73022. Disponível em: https://revistas.ufg.br/iptsp/article/view/73022/39687. Acesso em: 27 dez. 2023.
dc.identifier.doi10.5216/rpt.v52i1.73022
dc.identifier.issne- 1980-8178
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/24309
dc.language.isoeng
dc.publisherUniversidade Federal de Goiás
dc.publisher.countryBrasil
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RMG)
dc.publisher.initialsUFG
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectSpondias mombin
dc.subjectHyperlipidemic diet
dc.subjectAntimicrobial inhibition
dc.subjectObesity
dc.subjectStaphylococcus aureus
dc.titleEvaluation of the effects of SPONDIAS MOMBIN extract as an alternative antimicrobial drug
dc.typeArtigo

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