Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation
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2020
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Scorpion envenomation is a leading cause of morbidity and mortality among accidents caused
by venomous animals. Major clinical manifestations that precede death after scorpion
envenomation include heart failure and pulmonary edema. Here, we demonstrate that cardiac
dysfunction and fatal outcomes caused by lethal scorpion envenomation in mice are medi ated by a neuro-immune interaction linking IL-1 receptor signaling, prostaglandin E2, and
acetylcholine release. IL-1R deficiency, the treatment with a high dose of dexamethasone or
blockage of parasympathetic signaling using atropine or vagotomy, abolished heart failure
and mortality of envenomed mice. Therefore, we propose the use of dexamethasone
administration very early after envenomation, even before antiserum, to inhibit the produc tion of inflammatory mediators and acetylcholine release, and to reduce the risk of death.
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REIS, Mouzarllem B. et al. Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation. Nature Communications, London, v. 11, n. 1, e54332020, 2020. DOI: 10.1038/s41467-020-19232-8. Disponível em: https://www.nature.com/articles/s41467-020-19232-8. Acesso em: 29 jan. 2025.