Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation

dc.creatorReis, Mouzarllem Barros dos
dc.creatorRodrigues, Fernanda Luciano
dc.creatorSilva, Natalia Lautherbach Ennes da
dc.creatorKanashiro, Alexandre
dc.creatorSorgi, Carlos Arterio
dc.creatorMeirelles, Alyne Fávero Galvão
dc.creatorSilva, Carlos Alberto A.
dc.creatorZoccal, Karina Furlani
dc.creatorSouza, Camila de Oliveira Silva e
dc.creatorRamos, Simone Gusmão
dc.creatorMatsuno, Alessandra Kimie
dc.creatorGardinassi, Luiz Gustavo Araujo
dc.date.accessioned2025-02-04T15:44:04Z
dc.date.available2025-02-04T15:44:04Z
dc.date.issued2020
dc.description.abstractScorpion envenomation is a leading cause of morbidity and mortality among accidents caused by venomous animals. Major clinical manifestations that precede death after scorpion envenomation include heart failure and pulmonary edema. Here, we demonstrate that cardiac dysfunction and fatal outcomes caused by lethal scorpion envenomation in mice are medi ated by a neuro-immune interaction linking IL-1 receptor signaling, prostaglandin E2, and acetylcholine release. IL-1R deficiency, the treatment with a high dose of dexamethasone or blockage of parasympathetic signaling using atropine or vagotomy, abolished heart failure and mortality of envenomed mice. Therefore, we propose the use of dexamethasone administration very early after envenomation, even before antiserum, to inhibit the produc tion of inflammatory mediators and acetylcholine release, and to reduce the risk of death.
dc.identifier.citationREIS, Mouzarllem B. et al. Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation. Nature Communications, London, v. 11, n. 1, e54332020, 2020. DOI: 10.1038/s41467-020-19232-8. Disponível em: https://www.nature.com/articles/s41467-020-19232-8. Acesso em: 29 jan. 2025.
dc.identifier.issne- 2041-1723
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/26522
dc.language.isoeng
dc.publisher.countryGra-bretanha
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RMG)
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleInterleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation
dc.typeArtigo

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