Anti-inflammatory, antinociceptive, and vasorelaxant effects of a new pyrazole compound 5-(1-(2-fluorophenyl)-1H-pyrazol-4-yl)-1H-tetrazole: role of NO/cGMP pathway and calcium channels

Página do item simplificado
dc.creatorOliveira, Lanussy Porfiro de
dc.creatorFlorentino, Iziara Ferreira
dc.creatorSilva, Daiany Priscilla Bueno da
dc.creatorPazini, Francine
dc.creatorCarvalho, Flávio Silva de
dc.creatorSanz Lobón, Germán
dc.creatorVaz, Boniek Gontijo
dc.creatorRocha, Fabio Fagundes da
dc.creatorFajemiroye, James Oluwagbamigbe
dc.creatorGhedini, Paulo César
dc.creatorLiao, Luciano Morais
dc.creatorMenegatti, Ricardo
dc.creatorCosta, Elson Alves
dc.creatorOliveira, Thiago Sardinha de
dc.date.accessioned2023-07-06T13:52:31Z
dc.date.available2023-07-06T13:52:31Z
dc.date.issued2023
dc.description.abstractMolecular modification of compounds remains important strategy towards the discovery of new drugs. In this sense, this study presents a new pyrazole derivative 5-(1-(2-fluorophenyl)-1H-pyrazol-4-yl)-1H-tetrazole (LQFM039) and evaluated the anti-inflammatory, analgesic, and vasorelaxant effects of this compound as well the mechanisms of action involved in the pharmacological effects. For this, mice were orally treated with LQFM039 (17.5, 35, or 70 mg/kg) prior acetic acid-induced abdominal writhing, formalin, tail flick, and carrageenan-induced paw edema protocols. In addition, vascular reactivity protocols were made with aortic rings contraction with phenylephrine and stimulated with graded concentrations of LQFM039. Abdominal writhing and licking time in both neurogenic and inflammatory phases of formalin were reduced with LQFM039 without altering latency to nociceptive response in the tail flick test. Carrageenan-induced paw edema showed that LQFM039 reduces edema and cell migration. In addition, the mechanism of action of LQFM039 involves NO/cGMP pathway and calcium channels, since this new pyrazole derivate elicited concentration-dependent relaxation attenuated by Nω-nitro-l-arginine methyl ester and 1H-[1,2,4] oxadiazolo [4,3-alpha]quinoxalin-1-one, and blockade of CaCl2-induced contraction. Altogether, our finding suggests anti-inflammatory, antinociceptive, and vasorelaxant effect of this new pyrazole derivative with involvement of NO/cGMP pathway and calcium channels.pt_BR
dc.identifier.citationOLIVEIRA, Lanussy P. de et al. Anti-inflammatory, antinociceptive, and vasorelaxant effects of a new pyrazole compound 5-(1-(2-fluorophenyl)-1 H -pyrazol-4-yl)-1 H -tetrazole: role of NO/cGMP pathway and calcium channels. Canadian Journal of Physiology and Pharmacology, Ottawa, v. 101, n. 5, p. 216-225, 2023. DOI: 10.1139/cjpp-2022-0428. Disponível em: https://cdnsciencepub.com/doi/10.1139/cjpp-2022-0428. Acesso em: 28 jun. 2023.pt_BR
dc.identifier.doi10.1139/cjpp-2022-0428
dc.identifier.issn0008-4212I
dc.identifier.issne- 1205-7541
dc.identifier.urihttps://cdnsciencepub.com/doi/10.1139/cjpp-2022-0428
dc.language.isoengpt_BR
dc.publisher.countryCanadapt_BR
dc.publisher.departmentInstituto de Química - IQ (RMG)pt_BR
dc.rightsAcesso Restritopt_BR
dc.titleAnti-inflammatory, antinociceptive, and vasorelaxant effects of a new pyrazole compound 5-(1-(2-fluorophenyl)-1H-pyrazol-4-yl)-1H-tetrazole: role of NO/cGMP pathway and calcium channelspt_BR
dc.typeArtigopt_BR

Arquivos

Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Baixar

Coleções

IQ - Artigos publicados em periódicos