Ellagic acid inhibits iron-mediated free radical formation

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dc.creatorDalvi, Luana Taquette
dc.creatorMoreira, Daniel Carneiro Moreira
dc.creatorAndrade Junior, Roberto Gomes de
dc.creatorGinani, Janini Selva
dc.creatorAlonso, Antonio
dc.creatorLima, Marcelo Hermes
dc.date.accessioned2023-11-28T12:53:53Z
dc.date.available2023-11-28T12:53:53Z
dc.date.issued2017
dc.description.abstractPolyphenols are reported to have some health benefits, which are link to their antioxidant properties. In the case of ellagic acid (EA), there is evidence that it has free radical scavenger properties and that it is able to form complexes with metal ions. However, information on a possible link between the formation of iron-EA complexes and their interference in Haber-Weiss/Fenton reactions was not yet determined. Thus, the present study investigated the in vitro antioxidant mechanism of EA in a system containing ascorbate, Fe(III) and different iron ligands (EDTA, citrate and NTA). Iron-mediated oxidative degradation of 2-deoxyribose was poorly inhibited (by 12%) in the presence of EA (50 μM) and EDTA. When citrate or NTA - which form weak iron complexes - were used, the 2-deoxyribose protection increased to 89–97% and 45%, respectively. EA also presented equivalent inhibitory effects on iron-mediated oxygen uptake and ascorbyl radical formation. Spectral analyses of iron-EA complexes show that EA removes Fe(III) from EDTA within hours, and from citrate within 1 min. This difference in the rate of iron-EA complex formation may explain the antioxidant effects of EA. Furthermore, the EA antioxidant effectiveness was inversely proportional to the Fe(III) concentration, suggesting a competition with EDTA. In conclusion, the results indicate that EA may prevent in vitro free radical formation when it forms a complex with iron ions.
dc.identifier.citationDALVI, Luana T. et al. Ellagic acid inhibits iron-mediated free radical formation. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, Amsterdam, v. 173, p. 910-917, 2016. DOI: 10.1016/j.saa.2016.10.034. Disponível em: https://www.sciencedirect.com/science/article/pii/S1386142516306199?via%3Dihub. Acesso em: 12 set. 2023.
dc.identifier.doi10.1016/j.saa.2016.10.034
dc.identifier.issn1386-1425
dc.identifier.issne- 1873-3557
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1386142516306199?via%3Dihub
dc.language.isoeng
dc.publisher.countryHolanda
dc.publisher.departmentInstituto de Física - IF (RMG)
dc.rightsAcesso Restrito
dc.subjectAntioxidant
dc.subjectFree radical
dc.subjectPolyphenolIron
dc.subjectEllagic acid
dc.titleEllagic acid inhibits iron-mediated free radical formation
dc.typeArtigo

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