Metabolic adaptation of Paracoccidioides brasiliensis in response to in vitro Copper deprivation

Página do item simplificado
dc.creatorPititto, Guilherme
dc.creatorCurcio, Juliana Santana de
dc.creatorPereira, Maristela
dc.creatorBailão, Alexandre Melo
dc.creatorPaccez, Juliano Domiraci
dc.creatorTristão, Gabriel Brum
dc.creatorMorais, Camila Oliveira Barbosa de
dc.creatorSousa, Agenor de Castro Moreira dos Santos Júnior Marcelo Valle de
dc.creatorFontes, Wagner
dc.date.accessioned2024-08-16T12:05:45Z
dc.date.available2024-08-16T12:05:45Z
dc.date.issued2020
dc.description.abstractCopper is an essential micronutrient for the performance of important biochemical processes such as respiration detoxification, and uptake of metals like iron. Studies have shown that copper deprivation is a strategy used by the host against pathogenic fungi such as Cryptoccocus neoformans and Candida albicans during growth and development of infections in the lungs and kidneys. Although there are some studies, little is known about the impact of copper deprivation in members of the Paracoccidioides genus. Therefore, using isobaric tag labeling (iTRAQ)-Based proteomic approach and LC-MS/MS, we analyzed the impact of in vitro copper deprivation in the metabolism of Paracoccidioides brasiliensis. One hundred and sixty-four (164) differentially abundant proteins were identified when yeast cells were deprived of copper, which affected cellular respiration and detoxification processes. Changes in cellular metabolism such as increased beta oxidation and cell wall remodeling were described.
dc.identifier.citationPETITO, Guilherme et al. Metabolic adaptation of Paracoccidioides brasiliensis in response to in vitro Copper deprivation. Frontiers in Microbiology, Lausanne, v. 11, e1834, 2020. DOI: 10.3389/fmicb.2020.01834. Disponível em: https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2020.01834/full. Acesso em: 8 ago. 2024.
dc.identifier.doi10.3389/fmicb.2020.01834
dc.identifier.issne- 1664-302X
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/25291
dc.language.isoeng
dc.publisher.countrySuica
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RMG)
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleMetabolic adaptation of Paracoccidioides brasiliensis in response to in vitro Copper deprivation
dc.typeArtigo

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
Artigo - Guilherme Pititto - 2020.pdf
Tamanho:
4.23 MB
Formato:
Adobe Portable Document Format
Baixar
Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Baixar

Coleções

ICB - Artigos publicados em periódicos