Triggered release of paclitaxel from magnetic solid lipid nanoparticles by magnetic hyperthermia

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dc.creatorOliveira, Relton Romeis de
dc.creatorSantos, Marcus Carrião dos
dc.creatorPacheco, Maiulle Teixeira
dc.creatorBranquinho, Luis Cesar
dc.creatorSouza, Ana Luiza Ribeiro de
dc.creatorBakuzis, Andris Figueiroa
dc.creatorLima, Eliana Martins
dc.date.accessioned2023-11-21T15:44:50Z
dc.date.available2023-11-21T15:44:50Z
dc.date.issued2018
dc.description.abstractWe developed a magnetic solid lipid nanoparticles formulation of paclitaxel (PTX-loaded MSLNs) via emulsification-diffusion method. The physicochemical characterization of PTX-loaded MSLNs was performed by AFM, DLS, determination of entrapment efficiency (EE) and drug loading (DL), DSC, VSM, and physical stability. The in vitro effect of temperature and pulsed magnetic hyperthermia on drug release were studied. PTX-loaded MSLNs had a particle diameter around 250 nm with a narrow size distribution, spherical morphology, EE of 67.3 ± 1.2% and a DL of 17.1 ± 0.4 μg/mg. A decrease of the melting point of the lipid was observed following the preparation of the MSLNs. A threefold increase in the in vitro drug release rate was seen when temperature was raised from 25 to 43 °C. The lipid coating of MPs confer a temperature-dependent drug release and magnetic hyperthermia was used to trigger controlled PTX release from MSLNs.
dc.identifier.citationOLIVEIRA, Relton Romeis et al. Triggered release of paclitaxel from magnetic solid lipid nanoparticles by magnetic hyperthermia. Materials Science & Engineering: C, Amsterdam, v. 92, p. 547-553, 2018. DOI: 10.1016/j.msec.2018.07.011. Disponível em: https://www.sciencedirect.com/science/article/pii/S0928493117344648. Acesso em: 12 set. 2023.
dc.identifier.doi10.1016/j.msec.2018.07.011
dc.identifier.issn0928-4931
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0928493117344648
dc.language.isoeng
dc.publisher.countryHolanda
dc.publisher.departmentInstituto de Física - IF (RMG)
dc.rightsAcesso Restrito
dc.subjectPaclitaxel
dc.subjectMagnetic solid lipid nanoparticles
dc.subjectCancer therapy
dc.subjectMagnetic hyperthermia
dc.subjectThermoresponsive nanoparticles
dc.titleTriggered release of paclitaxel from magnetic solid lipid nanoparticles by magnetic hyperthermia
dc.typeArtigo

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