Estudo experimental comparando o uso do 2-octil cianoAcrilato ao nylon 4-0 na sutura da pele
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Data
2008-07
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Resumo
Background: Tissue adhesive 2-octyl cyanoacrylate was developed to have more strength, less inflammatory reaction, and less
histotoxicity than its shorter-chain derivates. Methods: To evaluate the use of 2-octil cyanoacrylate in comparison with “nylon”
suture in skin closure of rats. Methods: Twenty-five female Wistar rats were submitted to a 3cm surgical incision in each side
of the abdomen. The wound was closed with intradermic suture using “nylon” 4-0 in one side, and 2-octil cyanoacrylate on the
other side. After 7 days the thread was removed and the wound was checked for complications. After 40 days the wound aspect
was clinically evaluated. The rats were sacrificed; the scars were resected, and sent to the pathologist without the information
of which closing method was used. Results: There were 2 deaths during anesthesia or few days after surgery. The mean surgical
time was 136 seconds with the adhesive and 176 with “nylon” (P=0.003). The complications were: one hematoma in each
method (P=0.8), fifteen wound dehiscence with the adhesive and 11 with “nylon” (P=0.2), seven scars with a bad or fair aspect
with adhesive and 4 with “nylon” (P=0.3), three infections with adhesive and 2 with “nylon” 2 (P=0.4). Histological examination
showed median scar width of 1.119 micron with the adhesive and 1.800 with “nylon” (P=0.7). The mean thickness was 1.795
in the adhesive group versus 1.705 micron (P=0.7). Conclusion: Surgical adhesive showed the same aesthetical results, the
same strength, and the same complications as for “nylon” 4.0 sutures, but the adhesive decreased the surgical time.
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Técnicas de sutura, Ratos, modelo experimental, Pele, Cianoacrilatos/uso terapêutico, Nylons, Suture techniques, Skin, Cyanoacrylates/therapeutic use, Nylons, Rats, experimental model
Citação
FREITAS-JÚNIOR, Ruffo de et al. Estudo experimental comparando o uso do 2-octil cianoAcrilato ao nylon 4-0 na sutura da pele. Revista do Colégio Brasileiro de Cirurgiões, Rio de Janeiro, v. 35, n. 3, p. 194-198, 2008.