Serodiagnosis of chronic and acute Chagas´disease with Trypanosoma cruzi recombinant proteins: results of a collaborative study in six Latin American countries

Resumo

An enzyme-linked immunosorbent assay to diagnose Chagas’ disease by a serological test was performed with Trypanosoma cruzi recombinant antigens (JL8, MAP, and TcPo). High sensitivity (99.4%) and specificity (99.3%) were obtained when JL8 was combined with MAP (JM) and tested with 150 serum samples from chagasic and 142 nonchagasic individuals. Moreover, JM also diagnosed 84.2% of patients in the acute phase of T. cruzi infection

Descrição

Palavras-chave

Collaborative study, Trypanosoma cruzi, Chagas disease, Serodiagnosis

Citação

UMEZAWA, Eufrosina S.; LUQUETTI, Alejandro O.; LEVITUS, Gabriela; PONCE, Carlos; PONCE, Elisa; HENRIQUEZ, Diana; REVOLLO, Susana; ESPINOZA, Bertha; SOUSA, Octavio; KHAN, Baldip; SILVEIRA, José Franco da. Serodiagnosis of chronic and acute Chagas´disease with Trypanosoma cruzi recombinant proteins: results of a collaborative study in six Latin American countries. Journal of Clinical Microbiology, Washington, v. 42, n. 1, p. 449-452, Jan. 2004.