Genotoxic and histopathological biomarkers for assessing the effects of magnetic exfoliated vermiculite and exfoliated vermiculite in Danio rerio

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dc.creatorCáceres Vélez, Paolin Rocio
dc.creatorFascineli, Maria Luiza
dc.creatorGrisolia, Cesar Koppe
dc.creatorLima, Emilia Celma de Oliveira
dc.creatorSousa, Marcelo Henrique
dc.creatorMorais, Paulo Cesar de
dc.creatorAzevedo, Ricardo Bentes de
dc.date.accessioned2023-10-30T14:36:03Z
dc.date.available2023-10-30T14:36:03Z
dc.date.issued2016
dc.description.abstractMagnetic exfoliated vermiculite is a synthetic nanocomposite that quickly and efficiently absorbs organic compounds such as oil from water bodies. It was developed primarily to mitigate pollution, but the possible adverse impacts of its application have not yet been evaluated. In this context, the acute toxicity of magnetic exfoliated vermiculite and exfoliated vermiculite was herein assessed by genotoxic and histopathological biomarkers in zebrafish (Danio rerio). DNA fragmentation was statistically significant for all groups exposed to the magnetic exfoliated vermiculite and for fish exposed to the highest concentration (200 mg/L) of exfoliated vermiculite, whereas the micronucleus frequency, nuclear abnormalities and histopathological alterations were not statistically significant for the fish exposed to these materials. In the intestinal lumen, epithelial cells and goblet cells, we found the presence of magnetic exfoliated vermiculite and exfoliated vermiculite, but no alterations or presence of the materials-test in the gills or liver were observed. Our findings suggest that the use of magnetic exfoliated vermiculite and exfoliated vermiculite during standard ecotoxicological assays caused DNA damage in D. rerio, whose alterations may be likely to be repaired, indicating that the magnetic nanoparticles have the ability to promote genotoxic damage, such as DNA fragmentation, but not mutagenic effects.
dc.identifier.citationCÁCERES-VÉLEZ, Paolin Rocio et al. Genotoxic and histopathological biomarkers for assessing the effects of magnetic exfoliated vermiculite and exfoliated vermiculite in Danio rerio. Science of the Total Environment, Amsterdam, v. 551/552, p. 228-237, 2016. DOI:10.1016/j.scitotenv.2016.01.048. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0048969716300481?via%3Dihub. Acesso em: 30 out. 2023.
dc.identifier.doi10.1016/j.scitotenv.2016.01.048
dc.identifier.issne- 1879-1026
dc.identifier.issn0048-9697
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0048969716300481?via%3Dihub
dc.language.isoeng
dc.publisher.countryHolanda
dc.publisher.departmentInstituto de Química - IQ (RMG)
dc.rightsAcesso Restrito
dc.subjectIron oxide nanoparticles
dc.subjectEcotoxicology
dc.subjectBioindicators
dc.subjectZebrafish
dc.subjectWater purification
dc.titleGenotoxic and histopathological biomarkers for assessing the effects of magnetic exfoliated vermiculite and exfoliated vermiculite in Danio rerio
dc.typeArtigo

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