The expression of chemokines CCL19, CCL21 and their receptor CCR7 in oral squamous cell carcinoma and its relevance to cervical lymph node metastasis
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Data
2013
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Resumo
The purpose of this study is to determine the
expression of CCL19, CCL21, and CCR7 in samples of oral
squamous cell carcinoma (OSCC) and their relationship
with clinical and microscopic parameters. A comparative
analysis was made of the mRNA expression of these chemokines
and receptor in OSCC and normal oral mucosa. The
immunoexpression of CCR7, CCL19, and CCL21 was also
verified in OSCC and lymph nodes. Statistical significance
was accepted at P<0.05. Similar levels of CCR7, CCL19,
and CCL21 mRNA in OSCC and normal oral mucosa were
seen. A low expression of CCL19 and CCL21 in the intraand
peritumoral regions was observed. Scarce CCL19+ and
CCL21+ cells were also noted in metastatic and nonmetastatic
lymph nodes. No association was found between
the expression of these chemokines and clinical and microscopic
parameters. Our findings would suggest that CCL19
and CCL21 may not be associated with cervical lymph node
metastasis or other clinical and microscopic factors in
OSCC.
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Palavras-chave
CCL19, Lymph node, CCL21, Metastasis, CCR7, Oral squamous cell carcinoma, Chemokine
Citação
OLIVEIRA-NETO, Helenisa Helena et al. The expression of chemokines CCL19, CCL21 and their receptor CCR7 in oral squamous cell carcinoma and its relevance to cervical lymph node metastasis. Tumor Biology, New York, v. 34, n. 1, p. 65-70, 2013.