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Conversion of prostate adenocarcinoma to small cell carcinoma-like by reprogramming
(2016) Borges, Gisely Teotonio; Vencio, Eneida Franco; Sue-Ing, Quek; Chen, Adeline; Martinez Salvanha, Diego; Vêncio, Ricardo Zorzetto Nicoliello; Nguyen, Holly M.; Vessella, Robert L.; Cavanaugh, Christopher; Ware, Carol B.
The lineage relationship between prostate adenocarcinoma and small cell carcinoma was studied by using the LuCaP family of xenografts establishedfrom primary neoplasm to metastasis. Expression of four stem cell transcription factor (TF) genes, LIN28A, NANOG, POU5F1, SOX2, were analyzedin the LuCaP lines. These genes, when force expressed in differentiated cells, can reprogram the recipients into stem-like induced pluripotent stem(iPS) cells. Most LuCaP lines expressed POU5F1, while LuCaP 145.1, representative of small cell carcinoma, expressed all four. Through transcriptomedatabase query, many small cell carcinoma genes were also found in stem cells. To test the hypothesis that prostate cancer progression from“differentiated” adenocarcinoma to “undifferentiated” small cell carcinoma could involve re-expression of stem cell genes, the four TF genes weretransduced via lentiviral vectors into ﬁve adenocarcinoma LuCaP lines—70CR, 73CR, 86.2, 92, 105CR—as done in iPS cell reprogramming. Theresultant cells from these ﬁve transductions displayed a morphology of small size and dark appearing unlike the parentals. Transcriptome analysis ofLuCaP 70CR (“ ” to denote transfected progeny) revealed a unique gene expression close to that of LuCaP 145.1. In a prostate principal componentsanalysis space based on cell-type transcriptomes, the different LuCaP transcriptome datapoints were aligned to suggest a possible ordered sequence ofexpression changes from the differentiated luminal-like adenocarcinoma cell types to the less differentiated, more stem-like small cell carcinoma types,and LuCaP 70CR . Prostate cancer progression can thus be molecularly characterized by loss of differentiation with re-expression of stem cell genes.
Clinicopathologic predictors of survival in buccal squamous cell carcinoma
(2020) Marinelli, Lisa M.; Chatzopoulos, Kyriakos; Marinelli, John P.; Chen, Tiffany Y.; Collins, Andrea R.; Sotiriou, Sotiris; Raslan, Shahm W.; Vencio, Eneida Franco; Garcia, Joaquin J.; Janus, Jeffrey R.
Background Buccal squamous cell carcinoma (SCC) is a locoregionally aggressive malignancy, representing a small subset of oral cancers in North America. We investigated the prognostic value of several clinicopathologic factors in a cohort of patients diagnosed with buccal SCC. Methods Between years 1992 and 2017, 52 patients were diagnosed with conventional buccal SCC. Archival surgical pathology material was retrospectively reviewed for reportable findings according to the latest reporting guidelines published by the College of American Pathologists. Clinical data were obtained through chart review. Results The majority of patients were of older age, current or past smokers, and without specific gender predilection. Most presented at a clinically advanced stage and were treated with surgery alone, or surgery followed by adjuvant radiotherapy. The tumor recurred in about 40% of patients, and almost half of the patients died from the disease by the end of the follow-up period. The worst pattern of invasion (WPOI) was associated with greater depth of invasion (DOI) (P = .031) and perineural invasion (P < .001). In univariate analyses, older age (P = .004), positive nodal status (P = .047), lymphovascular invasion (P = .012), perineural invasion (P = .05), and WPOI-5 (P = .015) were adverse predictors of 5-year overall survival (OS). In multivariate analysis, older age (P = .011), WPOI-5 (P < .001), and perineural invasion (P = .001) remained statistically significant independent prognosticators of worse 5-year OS. Conclusions Older age, WPOI-5, and perineural invasion are significant prognosticators of worse OS. WPOI is associated with DOI, a finding which may have important implications for the pathogenesis and biologic behavior of the disease.
Glandular odontogenic cyst in dentigerous relationship: an uncommon case report
(2019) Ferreira, Jean Carlos Barbosa; Vencio, Eneida Franco; Sa, Rodrigo Tavares de; Gasperini, Giovanni
Glandular odontogenic cyst (GOC) is an uncommon cyst of the jaw. Less than 200 cases are reported in the literature, and only 22 cases are associated with an unerupted tooth (dentigerous relationship). Although it is an asymptomatic lesion, it can be destructive and has high recurrence rates. The diagnosis can be especially challenging due to the lack of distinct diagnostic clinic-radiological criteria and nonspecific microscopic features, mimicking benign and malignant lesions. Conservative surgical treatment has been the choice for most surgeons, but marginal or partial jaw resection has been reported. This report describes a rare case of GOC in a dentigerous relationship, which was treated with enucleation and peripheral osteotomy.
Dietary intake is associated with miR-31 and miR-375 expression in patients with head and neck squamous cell carcinoma
(2022) Ferreira, Tathiany Jéssica; Araújo, Caroline Castro de; Lima, Ana Carolina da Silva; Matida, Larissa Morinaga; Griebeler, Ana Flávia Mendes; Coelho, Alexandre Siqueira Guedes; Gontijo, Antônio Paulo Machado; Cominetti, Cristiane; Vencio, Eneida Franco; Horst, Maria Aderuza
MicroRNAs (miRNAs) are important epigenetic regulators in head and neck squamous cell carcinoma (HNSCC), with miR-31 being considered an oncomir and miR-375, a tumor suppressor miR, which are up- and down-regulated in HNSCC, respectively. Nutrients are known to influence miRNA expression; however, this association is poorly explored in HNSCC. This work aimed to identify associations between dietary intake and the expression of miR-31 and miR-375 in patients newly diagnosed with HNSCC. The expression of miR-31 was positively associated with the consumption of iron (β = 16.65) and vitamin C (β = 0.37), and inversely associated with total sugar (β = −0.88), cholesterol (β= −0.23), vitamin B9 (β= −0.37) and zinc (β = −5.66) intake. The expression of miR-375 was positively associated with the consumption of selenium (β = 1.52), vitamin C (β = 0.17) and vitamin D (β = 13.01), and inversely associated with the consumption of added sugar (β = −0.49), phosphorus (β= −0.27) and vitamin B12 (β = −10.80). Our findings showed important associations between dietary intake and miR-31 and miR-375 expression in HNSCC, offering possible directions for further studies investigating how nutrients interfere with carcinogenesis.
Expression of hypoxia-induced factor-1 alpha in early-stage and in metastatic oral squamous cell carcinoma
(2017) Ribeiro, Maisa; Teixeira, Sarah Rozette; Azevedo, Monarko Nunes de; Fraga Júnior, Ailton Cabral; Gontijo, Antônio Paulo Machado; Vencio, Eneida Franco
To investigate hypoxia-induced factor-1 alpha expression in distinct oral squamous cell carcinoma subtypes and topographies and correlate with clinicopathological data. Hypoxia-induced factor-1 alpha expression was assessed by immunohistochemistry in 93 cases of OSCC. Clinical and histopathological data were reviewed from medical records. Hypoxia-induced factor-1 alpha status was distinct according to tumor location, subtype and topography affect. In superficial oral squamous cell carcinomas, most tumor cells overexpressed hypoxia-induced factor-1 alpha, whereas hypoxia-induced factor-1 alpha was restricted to the intratumoral region in conventional squamous cell carcinomas. All basaloid squamous cell carcinomas exhibited downregulation of hypoxia-induced factor-1 alpha. Interestingly, metastatic lymph nodes (91.7%, p = 0.001) and the intratumoral regions of corresponding primary tumors (58.3%, p = 0.142) showed hypoxia-induced factor-1 alpha-positive tumor cells. Overall survival was poor in patients with metastatic lymph nodes. Hypoxia-induced factor-1 alpha has distinct expression patterns in different oral squamous cell carcinoma subtypes and topographies, suggesting that low oxygen tension promotes the growth pattern of superficial and conventional squamous cell carcinoma, but not basaloid squamous cell carcinoma. Indeed, a hypoxic environment may facilitate regional metastasis, making it a useful diagnostic and prognostic marker in primary tumors.
Clinical differential diagnosis between nonodontogenic and endodontic radiolucent lesions in periapical location: a critical review
(2021) Carvalho, Stephany Pimenta; Estrela, Carlos; Vencio, Eneida Franco
In endodontics, accurate diagnoses are important for the selection of appropriate and successful therapy. Several nonendodontic entities in periapical location may resemble those of inflammatory endodontic origin and impact therapeutic approaches. The aim of this study was to review noninflammatory entities mimicking dentoalveolar abscesses or apical periodontitis and to discuss clinical and pathological features. In this review study, the authenticated search engine in PubMed (MEDLINE) database was used to find articles by using “Nonvital Pulp Dentoalveolar Abscess”, “Nonvital Pulp And Apical Periodontitis”, “Periapical Abscess“, “Chronic Dentoalveolar Abscess”, “Chronic Apical Periodontitis”, “Periapical Granuloma”, And “Radicular Cyst”. Each of these predefined keywords were combined with the terms “Misdiagnosed”, “Mimicking”, “Masquerading”, or “Simulating” to search for reported cases indexed from 1978 to 2020. All case reports fulfilling the selection criteria were reviewed to identify radiolucent nonendodontic periapical lesions focused on the questions: “Which pathological entities mimick radiolucent endodontic lesions in periapical location? Based on endodontic clinical parameters, what are the contrasting features?” Out of 426 articles, 111 were relevant to the subject, including a series of cases and case reports. Only well-documented English and recent papers were considered. A total of 30 noninflammatory entities appeared clinically as radiolucent endodontic lesion in periapical location. Lesions simulating chronic apical periodontitis represented 83.3% and dentoalveolar abscess 16.7%. Interestingly, primary malignancies and metastasis counted 43.3% and pain was a typical symptom. Swelling was a noncontributory clinical feature in distinguishing periapical lesions. Lack of pulp response was registered in 68.4% of nonedodontic lesions. A flowchart was generated to summarize clinicopathological aspects of radiolucent nonendodontic entities appearing as dentoalveolar abscesses or apical periodontitis In relation to clinical practice, it is very important for us to note that, a group of pathological entities may simulate radiolucencies of endodontic origin in periapical location, especially malignancies and non-inflammatory odontogenic lesions.
A recurrent case of central odontogenic fibroma in maxilla showing root resorption: a case report
(2018) Carvalho, Stephany Pimenta; Watanabe, Satiro; Vencio, Eneida Franco
Objective: The aim of this report is present an aggressive re current case of central odontogenic fibroma (COF) with tooth resorption in anterior maxilla, and discuss both events based on literature. Case description: A 29-year-old woman was re ferred for examination of a non-swelling intraosseous lesion detected by routine radiographic exams for orthodontic plan ning. Panoramic exam revealed a well-defined multiloculated radiolucency in the right anterior maxilla. Periapical radiogra phy highlighted dental resorption of canine and first premolar. After the incisional biopsy the COF diagnosis was confirmed. Tumor was removed by enucleation. Recurrence was detected three years later and the lesion was removed together with in volved teeth. No indication of recurrence has been observed in the past eight years. Conclusion: COF is a benign tumor and can be aggressive. Recurrence and root resorption simultane ously are rare features reported in literature. The treatment must include tooth removal and curettage. Prognosis is good and follow-up is important.
Tratamento de cisto radicular de grande extensão: relato de caso clínico
(2018) Silva, Ricardo Natã Fonseca; Vilela, Ana Carolina Serafim; Ferreira, Alexandre Bellotti; Silva, Bruno Gomes da; Vencio, Eneida Franco; Decurcio, Daniel de Almeida; Costa, Nádia do Lago
To present the case of a large radicular cyst in the maxilla. Case report: Male patient, feoderma, 28 years old, at tended the stomatology service complaining of “a bubble in the tooth.” The patient reported the evolution of the injury for 15 days and has undergone previous endodontic treatment on the tooth 21. In intraoral physical examination it was observed a mild increase in the volume on anterior palate in the tooth 21 region. The anterior superior teeth responded negatively the pulp sensitivity test (PST). The panoramic radiography and den tal CT scan revealed a hypodense image expansive unilocular extending from the region of the tooth 16 to tooth 25 with par tially defined limits and move away of the right maxillary sinus floor and the nasal cavity. Treatment: Incisional biopsy was per formed and the result of the pathological examination suggested a radicular cyst. The initial therapeutic approach had been the endodontic treatment of teeth presented pulp necrosis prioritiz ing the use of calcium hydroxide as intracanal dressing. Histo pathological analysis showed a cystic lesion of inflammatory ori gin. After the endodontic treatment was made marsupialization of the lesion, aiming the cystic decompression. After 3 months of surgical decompression new imaging examination revealed a small regression of the lesion, however, is not satisfactory. We chose to realize curettage of the lesion under general anesthesia, reconfirming the diagnosis of radicular cyst. Conclusion: Cur rently, 10 months after surgery, new radiographs demonstrated the process of bone formation at the site of injury.
Metodologias de ensino no curso técnico de enfermagem
(2015-08) Araújo, Reila Campos Guimarães de; Nunes, Maria de Fátima
This study investigated the application of traditional and problematizing teaching methodologies in a Nursing technical course at Senac in Rio Verde, Goiás. The data collection was used: 1. Daily observation guide; 2. Values scales; 3. Anonymous questionnaire; 4. Formal evaluation. The methodologies showed difference in terms of motivation to students’ participation, with better result in problematizing methodology. The formal evaluation showed no difference in the learning process, except for participation topic. In the perception of the teachers, the problematizing methodology overlaps the traditional methodology.
Perfil dos usuários de um serviço de atendimento especializado em HIV/AIDS
(Universidade Federal de Goiás, 2020-12-31) Silveira, Jane Martins; Lemos, Cristiane Lopes Simão; Nunes, Maria de Fátima
The Specialized Care Service (SAE) is an important strategy of the Ministry of Health for the treatment of people living with the Human Immunodeficiency Virus - HIV / Acquired Immunodeficiency Syndrome - AIDS - aimed at reducing related morbidity and mortality AIDS in Brazil. The aim of this study was to know and describe the profile of users diagnosed with HIV / AIDS, who were admitted to SAE / Goiânia, in 2016. Method: In the total of study subjects, 168 (92.3%) were 126 males (69.3%) were between 20 and 34 years old; 55 (30.2%) had completed high school. A little more than half of the users 92 (50.5%) declared sexual intercourse as a way of contagion of HIV. The rate of users being treated with antiretroviral therapy (TARV) was 161 (88.5%). It was concluded that the majority of SAE / Goiânia users with HIV / Aids, in 2016, were men, with complete high school, young adults and who had the sexual route as the main route of HIV contagion. The rate of users undergoing treatment with antiretroviral therapy was 95.6% (174) there was abandonment of 4.7% (8 users) The most significant difference presented was in the gender variable, where viral suppression reached 92.3%, women undergoing TARV and only 57.4% of men had their viral load undetectable. This study contributed to the planning of assistance actions developed by the Municipal Health Department, for monitoring and supported future proposals for interventions such as: increasing the accessibility of the population in general, especially initiating actions that include the female and heterosexual population.
Bioética, legislação e tecnologias reprodutivas
(2001) Guilhem, Dirce Bellezi; Prado, Mauro Machado do
In this study, the authors focus on the bioethical and legal debate about the utilization of reproductive technologies in Brazil, presenting the path of the proposals that aim at regulating the clinical practice of human assisted reproduction. The following documents are used as reference for the analysis: the Resolution by the Federal Council of Medicine (CFM) n.1.358/92, the bills in the National Congress, laws and regulations related to the subject. The examination of these documents allows us to verify the different technical and moral orientations that influence the conduction of the issue in the legislative sphere. It can be verified that the main focus of the projects refers to the rights and interests of children, to the possible beneficiaries of the technique and to embryo reduction. Very little relevance has been directed to the issues of sexual and reproductive rights and to the health of women that undergo new reproductive technologies.
Análise bioética da percepção da solidariedade na ação do voluntariado
(2005) Penteado, Felipe Gomes; Silva, Leonardo Eustáquio Sant'Anna da; Rodrigues, Renata Dias Carneiro; Silva, Mauro Machado do; Bugarin Júnior, João Geraldo
El presente artículo consiste en un análisis de la percepción de solidariedad por voluntarios de una institución filantrópica del Distrito Federal dirigida al auxilio de familias que poseen niños en tratamiento de cáncer. Para lo cual, se aplicaron cuestionarios a los voluntarios relacionados con la institución y también participantes de una promoción filantrópica de una cadena internacional de fast food. Se analizó, según la bioética, si su comprometimiento ocurrió por cuestión de solidariedad, caridad o compasión. La referencia conceptual para el presente análisis es que la solidariedad consiste en una acción crítica, comprometida y en consonancia con varios principios bioéticos. El estudio hizo percibir que los voluntarios comprenden a la solidaridad como un proceso basado en la responsabilidad social y que tiene consciencia de que sus acciones son importantes para la sociedad.
Importância pericial dos registros odontológicos decorrentes de tratamento protético
(2008-12) Silva, Rhonan Ferreira da; Benta, Niusa Gomes; Daruge Júnior, Eduardo; Prado, Mauro Machado do; Melo, Mauro de
The dental records produced in the prosthetic treatments have primordially a clinical purpose, because these documents allow the consultation about the stage of execution of odontological procedures. However, in specific situations, the information contained in these documents may have relevant legal value, by clarifying several judicial questions. In cases related to the identification of edentulous individuals, the dentist must be attentive to register all possible details about the oral anatomy of the patient and denture features. In this context, the aim of this work is to show the forensic importance of prosthetic records, through a case report, by emphasizing the social and legal importance of establishing denture marking standards. Until the Federal Council of Dentistry establishes specific rules concerning the matter, and to be followed by dentists and technical in dental prosthesis, these professionals must observe their ethical and legal obligations related to the notes and data about clinical and laboratorial prosthetic procedures that they have to register in patient’s record. Thus, these dental records may protect the professional exercise and subsidize correctly the forensic exams in cases of edentulous patients.
Alterações na Declaração de Helsinque – a história continua
(2007) Garrafa, Volnei; Prado, Mauro Machado do
The following article analyses the history paper played by Helsink Statement in the field of ethics in research with humans beings. The aforesaid document, built and reviewed several times during annual Meetings promoted by The World Medical Association, nevertheless began to receive severe criticism of the USA from the years 90's. Concerning this document, mainly, the articles 19, 29, and 30 had their legitimacy put under challenge. The referred articles are related to a double standard research usage as ethics measurement and a non obligation for clinical investigation sponsors to keep themselves responsible for any attention those related subjects after completed assays. This document analyses all long process for changing attempts, severely criticized under bioethics about the point of view, sided and imperialist US positions.
Responsabilidade profissional no atendimento de pacientes com traumatismo dentário
(2009-03) Silva, Rhonan Ferreira da; Portilho, Claudia Daniela Moreira; Daruge Júnior, Eduardo; Prado, Mauro Machado do; Garcia, Robson Rodrigues
Dentoalveolar trauma may be caused by various factors such as aggression, accidental impacts and traffic accidents. Depending on the type of trauma associated with the region and teeth affected, the dental procedures may be conservative or more invasive, including the indication of extraction of traumatized teeth. Bearing in mind that, in addition to the clinical repercussions, dentoalveolar trauma may be associated with legal proceedings, instituted in various areas of law (civil, criminal, security, etc), this paper shows, on the basis of a clinical case, the importance of dental records and the professional liability of the dentist treating a patient suffering from orofacial trauma. The practitioner must therefore take care to record in detail all information obtained from the clinical treatments performed, duly filing the patient’s record and all other documents resulting from clinical practice with a view to safeguarding his or her professional conduct and the particular rights of the patient.
Quantos pontos de concordância são necessários para se obter uma identificação odontolegal positiva?
(2009-04) Silva, Rhonan Ferreira da; Prado, Mauro Machado do; Daruge Júnior, Eduardo
The present paper consists in a case study about human identification by comparative technique, through a forensic dental method in which the aspects of quantity and quality of necessary points of concordance for a positive identification are discussed. Although some studies point out a minimum of twelve convergent points, as established in the fingerprint analysis, the quantitative evaluation must appear parallel to a quantitative analysis. The authors pose that a positive identification based on different signs present in each case is possible without necessarily mattering the number of concordances.
A importância da atuação do odontolegista no processo de identificação humana de vítimas de desastre aéreo
(2011) Leite, Murillo Martins; Amorim, Ana Célia de Oliveira; Gomes, Tiago Dias; Silva, Rhonan Ferreira da
The dental expert´s field range from expertise in administrative, criminal or civil courts to human identification. The role of this professional in identification is extremely important in cases of mass casualties, especially concerning the air crash, which, in dimension, results in charred bodies, or fragmented ones and often in an advanced state of decomposition. Under these circumstances, the method of dental comparison becomes essential, and also a simple technique, not expensive, quick and effective due to the need of a large number of identifications in a short time. Objective: Given the above, this study aims to examine the professional profile as well as the role of dental expert’s in the context of activities in human identification of air disaster victims occurred in the last decade in Brazil. Material and method: The methodology consisted in literature review and, then, field research, involving interviews with three dentists that participated in the identification of air disaster victims that occurred in Brazil, and further analysis of their reports. Results: The results point out to a convergence between the views of respondents regarding: the importance of the dental expert’s and of the dental records. Conclusion: It was possible to conclude that the performance of the dental expert’s is crucial in the process of identification of airplane crash victims; that the greatest difficulties in identifying these victims are the fact that most of them were burned and / or fragmented and the lack of antemortem material to conduct dental confrontation; and that Brazil should be better prepared to act efficiently on this kind of mass disaster.
Compreensão e legibilidade do termo de consentimento livre e esclarecido em pesquisas clínicas
(2014-08) Rodrigues Filho, Euripedes; Prado, Mauro Machado do; Prudente, Cejane Oliveira Martins
Este artículo es una revisión integradora de la literatura cuyo objetivo fue analizar la comprensión y la legibilidad de los consentimientos informados de los participantes de las investigaciones con seres humanos; y comprobar cuáles son los factores que influyen en su comprensión y legibilidad. Por lo tanto, se buscó identificar los factores asociados con el problema de la obtención del consentimiento válido. Forman parte de la muestra de esta revisión once artículos seleccionados, nacionales e internacionales, de los cuales cuatro eran en portugués (36, 36%), uno en español (9,10%) y seis en inglés (54,54%). Se concluyó que la mayoría de los estudios analizados confirma la hipótesis de que los participantes no entienden lo que leen en el consentimiento informado. Así, los factores deducidos como responsables de la dificultad para la lectura y la comprensión de los consentimientos informados fueron el nivel educativo de los participantes y el lenguaje usado en los términos.
Verificação do uso de próteses dentárias em servidores da UFG
(2015) Prado, Mauro Machado do; Borges, Raulino Naves; Prado, Mauro Machado do; Freitas, Gersinei Carlos de; Alvim, Taís G. M.; Melo, Tatiany Cristine de Almeida Silva
Objective: This study aims to verify the use of dental prostheses on servers at the Federal University of Goiás Methods:. It is this work of documentary research through a retrospective survey of the use of qualitative and quantitative dentures among the technical and administrative staff of the Federal University of Goiás in the five-year period. Data collection strategies were at filling the data in an appropriate form, grounded in the literature. Results: The sample consisted of 50 charts analyzed, of which 26% are non users of prosthesis and the other 74% are carriers of prostheses, of which 57% are women and 43% are men. This sample analyzed, it was found that 56.76% showed with fixed partial denture; 5.41% prosthesis over the implant; 2.70% Total prosthesis bimaxilar; 29.73% Total prosthesis associated with a removable partial denture; 2.70% Total dentures, fixed and removable; 2.70% dentures. Conclusion: Based on these results, it is suggested that increases subsidies and programs for the probable redirection service, as well as to establish promotion and health prevention policies.
Phenotypic aspects of oral strains of C. albicans in children with Down's syndrome
(2006) Ribeiro, Evandro Leão; Scroferneker, Maria Lúcia; Carvalhaes, Mara Silvia; Campos, Cerise de Castro; Nagato, Gustavo M.; Souza, Niwmar A. de; Cardoso, Cléver Gomes; Ferreira, W. M.; Pimenta, Fabiana Cristina; Toledo, Orlando Ayrton de
The aim of this article is to characterize the biological aspects of oral strains of C. albicans in children with Down’s syndrome. These yeasts were analyzed as to their macromorphological and enzymatic aspects and were tested as to their in vitro susceptibility to antifungal drugs using broth microdilution to determine the minimum inhibitory concentration (MIC). The morphotyping revealed that all oral C. albicans isolates from children with Down’s syndrome promoted the formation of fringes regardless of size, while the control group presented smaller fringes. All oral C. albicans strains produced proteinase, but those with phospholipolytic activity showed greater enzyme capacity in the test group. In vitro susceptibility showed that all oral C. albicans isolates were sensitive to the drugs used.

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