Impact of meningococcal C conjugate vaccination four years after introduction of routine childhood immunization in Brazil

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dc.creatorAndrade, Ana Lúcia Sampaio Sgambatti de
dc.creatorMinamisava, Ruth
dc.creatorTomich, Lísia Gomes Martins de Moura
dc.creatorLemos, Ana Paula Silva de
dc.creatorGorla, Maria Cecilia Outeiro
dc.creatorBrandileone, Maria Cristina de Cunto
dc.creatorDomingues, Carla Magda Allan Santos
dc.creatorMoraes, Camile de
dc.creatorPolicena, Gabriela Moreira
dc.creatorBierrenbach, Ana Luiza de Souza
dc.date.accessioned2024-08-22T13:54:44Z
dc.date.available2024-08-22T13:54:44Z
dc.date.issued2017
dc.description.abstractBackground: Routine infant immunization with meningococcal C conjugate (MCC) vaccination started in Brazil in November 2010, scheduled at three and five months plus a booster at 12–15 months of age. No catch-up was implemented. We assessed the impact of vaccination on meningococcal C disease (MenC) four years after vaccination start in the National Immunization Program. Methods: We performed an ecological quasi-experimental design from 2008 to 2014 using a determinis tic linkage between the National Notification and the National Reference Laboratory databases for menin gitis. We conducted an interrupted time-series analysis considering Brazil except for Salvador municipality, because an epidemic of serogroup C disease occurred in this city, which prompted a mass vaccination campaign with catch-up for adolescents in 2010. Observed MenC rates in the post vaccination period were compared to expected rates calculated from the pre-vaccination years. Results for Salvador were presented as descriptive data. An additional time-series analysis was performed for the state of São Paulo. Results: A total of 18,136 MenC cases were analyzed. The highest incidence rates were observed for infants aged <12 months and no second incident peak was observed for adolescents. For Brazil, MenC rates were reduced by 67.2% (95%CI 43.0–91.4%) for infants <12 months of age, 92.0% (77.3–106.8%) for the age-group 12–23 months, and 64.6% (24.6–104.5%) for children aged 2–4 years. For children 5– 9 years old, MenC rates reduced 19.2% (9.5–28.9%). Overall, 955 MenC cases were averted in Brazil in individuals aged <40 years after MCC vaccination. Results from São Paulo State, mirror the patterns seen in Brazil. Conclusion: After four years of infants and toddlers vaccination start, MenC invasive disease reduced in the target population. This investigation provide a robust baseline to ascertain how much the upcoming catch-up dose in 12–13 years of age will accelerate the decrease in MenC incidence rates among youths in Brazil.
dc.identifier.citationANDRADE, Ana Lucia et al. Impact of meningococcal C conjugate vaccination four years after introduction of routine childhood immunization in Brazil. Vaccine, Amsterdam, v. 35, n. 16, p. 2025-2033, 2017. DOI: 10.1016/j.vaccine.2017.03.010. Disponível em: https://www.sciencedirect.com/science/article/pii/S0264410X1730316X. Acesso em: 12 ago. 2024.
dc.identifier.doi10.1016/j.vaccine.2017.03.010
dc.identifier.issn0264-410X
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/25370
dc.language.isoeng
dc.publisher.countryHolanda
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RMG)
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectInvasive meningococcal disease
dc.subjectSerogroup C meningococcal disease
dc.subjectMeningococcal vaccines
dc.subjectVaccination impact
dc.subjectSurveillance
dc.subjectData linkage
dc.subjectInterrupted time-series analysis
dc.subjectNeisseria meningitidis
dc.titleImpact of meningococcal C conjugate vaccination four years after introduction of routine childhood immunization in Brazil
dc.typeArtigo

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