Expression of VEGF-A in intraepithelial and invasive cervical neoplasia
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Data
2015-11-18
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Resumo
Angiogenesis seems to be an early event that is associated with disease progression in cervical intraepithelial
neoplasia (CIN). The aim of this study was to describe and analyze VEGF-A expression in CIN 3 and invasive
cervical carcinoma, in tumor cells and stromal cells. This study comprised three groups: Group 1: 53 cases with CIN
3; Group 2: 24 cases with both CIN 3 and invasive carcinoma components; Group 3: 36 cases with invasive
carcinoma. Protein expression was investigated in tumor and stromal cells by immunohistochemistry. Statistical
analysis was carried out, considering the mean percentage of immunopositive cells. VEGF-A expression was higher
in stromal cells in cases of invasive carcinoma (Group 3) than in CIN 3 cases (Group 1) and this difference was
statistically significant. VEGF-A expression showed a borderline association between stromal cells in invasive
carcinoma (Group 3) and invasive carcinoma associated with CIN 3 (Group 2). The mean percentage of cells
expressing VEGF-A was significantly higher in tumor cells in CIN 3 than in stromal cells in CIN 3 (Group 1). The
progression of CIN 3 to invasive carcinoma seems be determined by complex interactions between tumor and
stromal cells. These findings reinforce the evidence of the role of stromal cells in tumor invasiveness
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Angiogenesis inducers, VEGF-A, Uterine cervical
Citação
WESTIN, Maria Cristina do Amaral et al. Expression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2 in intraepithelial and invasive cervical neoplasia. Journal of Cytology and Histology, Brussels, v. 2, nesp, p. 2-5, Nov. 2015.