Epidemiological aspects of hepatitis C virus infection among renal transplant recipients in central Brazil

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dc.creatorBotelho, Silvia Marçal
dc.creatorFerreira, Renata Carneiro
dc.creatorReis, Nádia Rúbia da Silva
dc.creatorKozlowski, Aline Garcia
dc.creatorCarneiro, Megmar Aparecida dos Santos
dc.creatorYoshida, Clara Fumiko Tachibana
dc.creatorMartins, Regina Maria Bringel
dc.date.accessioned2019-09-26T13:41:26Z
dc.date.available2019-09-26T13:41:26Z
dc.date.issued2008-08
dc.description.resumoAn investigation was conducted involving 255 renal transplant recipients in the state of Goiás, Central Brazil, to determine the prevalence of hepatitis C virus (HCV), its risk factors, the genotypes involved, and the level of alanine aminotransferase (ALT) present in the patients. All serum samples were tested for anti-HCV antibodies and HCV RNA. Forty-one patients were anti-HCV and/or HCV RNA positive, resulting in an overall HCV infection prevalence of 16.1% (95% CI: 11.9-21.3). A multivariate analysis of risk factors showed that a history of blood transfusions without anti-HCV screening, the length of time spent on hemodialysis, and renal transplantation before 1994 are all associated with HCV positivity. In HCV-positive patients, only 12.2% had ALT levels above normal. Twenty-eight samples were genotyped as genotype 1, subtypes 1a (62.5%) and 1b (31.3%), and two samples (6.2%) were genotype 3, subtype 3a. These data show a high prevalence of HCV infection and low ALT levels in the studied population. The risk factor analysis findings emphasize the importance of public health strategies such as anti-HCV screening of candidate blood and organ donors, in addition to the stricter adoption of hemodialysis-specific infection control measures. The present study also demonstrates that HCV genotype 1 (subtype 1a) is predominant in this populationpt_BR
dc.identifier.citationBotelho, Silvia M.; FERREIRA, Renata C.; REIS, Nádia R. S.; KOZLOWSKI, Aline G.; CARNEIRO, Megmar A. S.; YOSHIDA, Clara F. T.; MARTINS, Regina M. B.; TELES, S. A. Epidemiological aspects of hepatitis C virus infection among renal transplant recipients in central Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 5, p. 472-476, Aug. 2008.pt_BR
dc.identifier.doi10.1590/S0074-02762008000500011
dc.identifier.issn1678-8060
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/18197
dc.language.isoporpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFaculdade de Enfermagem - FEN (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectHepatitis C viruspt_BR
dc.subjectRenal transplant recipientspt_BR
dc.subjectPrevalencept_BR
dc.subjectRisk factorspt_BR
dc.subjectALTpt_BR
dc.subjectGenotypespt_BR
dc.titleEpidemiological aspects of hepatitis C virus infection among renal transplant recipients in central Brazilpt_BR
dc.typeArtigopt_BR

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