Late diagnosis and TCD8 immune response profile of cutaneous tuberculosis: a case report
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Data
2012
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Introduction: Cutaneous tuberculosis (CTB) is a rare form of extra-pulmonary tuberculosis that, when associated with late diagnosis, worsen the quality of life of the sick individuals. This report presents a case of late diagnosis of CTB. Un-usual clinical manifestations retarded the cor-rect tuberculosis diagnosis for more than a year. The immune response elicited by this type of tuberculosis as well as the factors that might contribute to the delay in diagnosis was evalu-ated and discussed. Methodology: Clinical evaluation and flow cytometric analyses of PBMC were realized for a case of CTB and a healthy individual as a control. Results: M. tu-berculosis specific TCD8+ cell response was analyzed by flow cytometry and revealed posi-tive cells for IL-17, IL-10, TGF-β and IDO. The CTB patient presented higher percentage of those cells when compared to a healthy donor. However, TCD8 cells positive for the important protective cytokine, IFN- was decreased in the CTB patient. Conclusion. The assessment of the M. tuberculosis specific TCD8+ immune re-sponse showed a regulatory/modulatory phe-notype with a reduced IFN- response when compared to the healthy control that could have contributed to the CTB infection.
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CD8+ T Cells, Cutaneous tuberculosis, Late Diagnosis
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SILVA, Bruna Daniella de Souza; ALVESA, Sueli Lemes de Ávila; KIPNIS, André; JUNQUEIRA-KIPNIS, Ana Paula. Late diagnosis and TCD8 immune response profile of cutaneous tuberculosis: a case report. Open Journal of Immunology, Delaware, v. 2, n.3, p. 125-131, 2012.