Late diagnosis and TCD8 immune response profile of cutaneous tuberculosis: a case report

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dc.creatorSilva, Bruna Daniella de Souza
dc.creatorAlves, Sueli Lemes de Ávila
dc.creatorKipnis, André
dc.creatorJunqueira-Kipnis, Ana Paula
dc.date.accessioned2018-12-12T11:51:18Z
dc.date.available2018-12-12T11:51:18Z
dc.date.issued2012
dc.description.abstractIntroduction: Cutaneous tuberculosis (CTB) is a rare form of extra-pulmonary tuberculosis that, when associated with late diagnosis, worsen the quality of life of the sick individuals. This report presents a case of late diagnosis of CTB. Un-usual clinical manifestations retarded the cor-rect tuberculosis diagnosis for more than a year. The immune response elicited by this type of tuberculosis as well as the factors that might contribute to the delay in diagnosis was evalu-ated and discussed. Methodology: Clinical evaluation and flow cytometric analyses of PBMC were realized for a case of CTB and a healthy individual as a control. Results: M. tu-berculosis specific TCD8+ cell response was analyzed by flow cytometry and revealed posi-tive cells for IL-17, IL-10, TGF-β and IDO. The CTB patient presented higher percentage of those cells when compared to a healthy donor. However, TCD8 cells positive for the important protective cytokine, IFN- was decreased in the CTB patient. Conclusion. The assessment of the M. tuberculosis specific TCD8+ immune re-sponse showed a regulatory/modulatory phe-notype with a reduced IFN- response when compared to the healthy control that could have contributed to the CTB infection.pt_BR
dc.identifier.citationSILVA, Bruna Daniella de Souza; ALVESA, Sueli Lemes de Ávila; KIPNIS, André; JUNQUEIRA-KIPNIS, Ana Paula. Late diagnosis and TCD8 immune response profile of cutaneous tuberculosis: a case report. Open Journal of Immunology, Delaware, v. 2, n.3, p. 125-131, 2012.pt_BR
dc.identifier.doi10.4236/oji.2012.23015
dc.identifier.issne- 2162-4526
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/16568
dc.language.isoengpt_BR
dc.publisher.countryEstados unidospt_BR
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectCD8+ T Cellspt_BR
dc.subjectCutaneous tuberculosispt_BR
dc.subjectLate Diagnosispt_BR
dc.titleLate diagnosis and TCD8 immune response profile of cutaneous tuberculosis: a case reportpt_BR
dc.typeArtigopt_BR

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