Aplicações tecnológicas do polimorfismo farmacêutico
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Data
2010-12
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Resumo
Pharmaceutical solids can present different crystal structure assemblies. Such
phenomenon is defi ned as polymorphism and can impact on pharmacotechnical
and pharmacokinetic features of drugs. The use of a wrong polymorph for
incorporation into drug formulations or phase transformations during processing
and storage can lead to pharmaceutical ineffectiveness or even toxicity. This
means that the knowledge of all polymorphs of a drug is crucial to ensure a
reproducible behavior of medicines and safety. On the other hand, crystal
engineering of molecular solids, which is based on rational supramolecular
synthesis of novel crystal forms, is an attractive alternative to improve
pharmaceutical properties without either cleaving or forming covalent bonds.
This work aims to present the main issues related to polymorphism, crystal
engineering strategies and solid state techniques for characterization and quality
control of drug polymorphs.
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Sólidos farmacêuticos, Polimorfismo, Engenharia de cristais moleculares, Pharmaceutical solids, Polymorphism, Crystal engineering
Citação
MARTINS, Felipe T. Aplicações tecnológicas do polimorfismo farmacêutico. Revista Processos Químicos, Goiânia, v. 4, n. 8, p. 9-21, jul./dez. 2010.