Caracterização físico-química, mecânica e térmica de potenciais formulações de hidrogéis para a impressão 3D de formas farmacêuticas

Abstract

3D printing has emerged as a promising technology for the development of customized pharmaceutical dosage forms, enabling the production of complex systems that can be adjusted to therapeutic needs. In this context, hydrogels represent relevant materials due to their high hydration, versatility, and ease of extrusion during the printing process. This work aimed to characterize three hydrogel formulations with potential application in 3D printing of pharmaceutical dosage forms: 50% w/w PVP; PVP and PEG; PVP, PEG and alginate. To this end, chemical analyses were performed using Fourier transform infrared spectroscopy (FTIR), mechanical analyses were performed using thermogravimetry (TGA) and differential thermal analysis (DTA). Each formulation presented specific characteristics related to its composition, such as chemical interaction between components, mechanical response, and dehydration and thermal degradation curves, providing information for the selection of potentially suitable systems for the preparation of hydrogels intended for 3D printing of pharmaceutical forms.