Occult hepatitis B virus infection among injecting drug users in the central-west region of Brazil

Resumo

The prevalence of occult hepatitis B virus (HBV) infection was investigated in 149 hepatitis B surface antigen (HB- sAg) negative injecting drug users (IDUs) in the Central-West Region of Brazil. Of these individuals, 19 were positive for HBV DNA, resulting in an occult HBV infection prevalence of 12.7% (19/149); six of these 19 individuals had anti- HBV core and/or anti-HBV surface antibodies and 13 were negative for HBV markers. All IDUs with occult hepatitis B reported sexual and/or parenteral risk behaviours. All HBV DNA-positive samples were successfully genotyped. Genotype D was the most common (17/19), followed by genotype A (2/19). These findings reveal a high prevalence of occult HBV infection and the predominance of genotype D among IDUs in Brazil’s Central-West Region.

Descrição

Palavras-chave

Hepatitis B virus, Genotypes, Occult infection

Citação

MATOS, Marcia Alves Dias de; FERREIRA, Renata Carneiro; RODRIGUES, Fabiana Perez; MARINHO, Tamiris Augusto; LOPES, Carmen Luci Rodrigues; NOVAIS, Antonia Carlos Magalhães; MOTTA-CASTRO, Ana Rita Coimbra; TELES, Sheila Araujo; SOUTO, Francisco Jose Dutra; MARTINS, Regina Maria Bringel. Occult hepatitis B virus infection among injecting drug users in the central-west region of Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 108, n. 3, p. 386-389, May 2013.