Analgesic and anti-inflammatory effects of Cheiloclinium cognatum root barks
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Data
2007-12
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Resumo
Cheiloclinium cognatum (Hippocrateaceae) has been used in folk medicine to
treat fever and edema. In this paper, we report the anti-infl ammatory and analgesic activities of
the crude dichloromethane extract (DECc) from C. cognatum root barks collected in Auguste
de Saint Hilaire wood at Universidade Federal de Goiás. Doses of 0.1, 0.3 and 1.0 g/kg caused
a dose-dependent inhibition of croton oil-induced ear edema in mice equivalent to 21, 30 and
51%, respectively. There was a signifi cant increase in analgesic-meter-induced tail fl ick test
equivalent to 105, 189 and 200% of increase tail fl ick reaction time. These results allowed to
suggest that C. cognatum could be a source of new compounds which anti-infl ammatory and
analgesic activities.
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Palavras-chave
Cheiloclinium cognatum, Hippocrateaceae, Efeito antiinfl amatório, Atividade analgésica, Edema de orelha, Peritonite, Anti-infl ammatory effect, Analgesic activity, Ear edema, Peritonitis
Citação
COSTA, Elson A, et al. Analgesic and anti-inflammatory effects of Cheiloclinium cognatum root barks. Revista Brasileira de Farmacognosia, Curitiba, v. 17, n. 4, p. 508-513, Oct./Dec. 2007.