Nanossistemas para administração oral de fármacos: uma revisão da literatura sobre os tipos, as estratégias e os desafios biofarmacotécnicos

Abstract

Introduction: nanocarriers are nanoscale systems used in drug delivery, aiming to enhance efficacy and reduce adverse effects. This thesis presents a literature review on the use of nanocarriers in pharmacology, highlighting their advantages over conventional drug administration forms. The context emphasizes the importance of nanocarriers in the protection and controlled release of active ingredients, as well as overcoming the biopharmaceutical limitations observed in oral drug administration. Objective: to describe the main types of nanocarriers used in oral delivery, discuss the challenges related to the production and application of these systems, and review the clinical applications already developed. Methodology: this work is a descriptive literature review, employing electronic database searches and qualitative analysis of the selected data. Results: the main results highlight the challenges encountered during passage through the gastrointestinal tract. Additionally, it exemplifies the efficiency of nanocarriers in protecting active ingredients, improving absorption, and reducing adverse effects. Conclusion: nanocarriers show potential in oral drug delivery, offering advantages over conventional pharmaceutical forms and minimizing many of the biopharmaceutical challenges presented by drugs when administered orally.