Estudo da ligação cruzada induzida pelo formaldeído em cápsulas de gelatina dura
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Data
2005-12
Título da Revista
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Editor
Marize Campos Valadares
Resumo
Formaldehyde induced cross-linking in gelatin can be used to promote gastric-resistance in gelatin
based oral drug delivery systems. However, thorough evaluations for each drug class must be performed before
establishing its use for this purpose. In this work, formaldehyde induced cross-linking in hard gelatin capsules was
investigated. Capsules were immersed in hydroalcoholic (70-90%) solutions containing several different
concentrations of formaldehyde. Cross-linking was evaluated by the determination of free amino groups in the
samples by UV spectrophotometry. Residual formaldehyde was determined by HPLC. Cross-linking reaction was
strongly influenced by water and alcohol concentrations in the solutions used for the treatment of the capsules.
Residual formaldehyde was within acceptable range. However, repeated analysis during a short term storage of
the capsules proved that the cross-linking continues as long as any residual formaldehyde is present, leading to a
much higher resistance than what would be convenient for the oral drug delivery.
Descrição
Palavras-chave
Gastro-resistência, Cápsulas de gelatina, Formaldeído, Ligação-cruzada, Gastric-resistance, Gelatin capsules, Formaldehyde, Cross-linking
Citação
ZAMPIERI, Ana Lúcia Teixeira de Carvalho; LIMA, Eliana Martins; DINIZ, Danielle Guimarães Almeida. Estudo da ligação cruzada induzida pelo formaldeído em cápsulas de gelatina dura. Revista Eletrônica de Farmácia, Goiânia, v. 2, n. 2, p. 73-79, jul./dez. 2005. Disponível em: <https://www.revistas.ufg.br/REF/article/view/1951/1884>.