Anti-inflammatory and antinociceptive activity profile of a new lead compound – LQFM219

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dc.creatorGalvão, Gustavo Mota
dc.creatorFlorentino, Iziara Ferreira
dc.creatorSanz Lobón, Germán
dc.creatorVaz, Boniek Gontijo
dc.creatorLiao, Luciano Morais
dc.creatorSabino, José Ricardo
dc.creatorCardoso, Cariina Sofia
dc.creatorSilva, Daiany Priscilla Bueno da
dc.creatorCosta, Elson Alves
dc.creatorSilva, Andreia Luiza Pereira
dc.creatorSilva, Artur Christian Garcia da
dc.creatorValadares, Marize Campos
dc.creatorLeite, Jacqueline Alves
dc.creatorGil, Eric de Souza
dc.creatorMenegatti, Ricardo
dc.date.accessioned2023-07-31T13:41:03Z
dc.date.available2023-07-31T13:41:03Z
dc.date.issued2020
dc.description.abstractLQFM219 is a molecule designed from celecoxibe (COX-2 inhibitor) and darbufelone (inhibitor of COX-2 and 5-LOX) lead compounds through a molecular hybridisation strategy. Therefore, this work aimed to investigate the antinociceptive and anti-inflammatory activities of this new hybrid compound. The acute oral systemic toxicity of LQFM219 was evaluated via the neutral red uptake assay. Acetic acid-induced abdominal writhing and CFA-induced mechanical hyperalgesia were performed to evaluate the antinociceptive activity, and the anti-oedematogenic activity was studied by CFA-induced paw oedema and croton oil-induced ear oedema. Moreover, the acute anti-inflammatory activity was determined by carrageenan-induced pleurisy. In addition, cell migration, myeloperoxidase enzyme activity, and TNF-α and IL-1β levels were determined in pleural exudate. Moreover, a redox assay was conducted using electroanalytical and DPPH methods. The results demonstrated that LQFM219 was classified as GHS category 4, and it showed better free radical scavenger activity compared to BHT. Besides, LQFM219 decreased the number of writhings induced by acetic acid and the response to the mechanical stimulus in the CFA-induced mechanical hyperalgesia test. Furthermore, LQFM219 reduced oedema formation, cell migration, and IL-1β and TNF-α levels in the pleural cavity and inhibited myeloperoxidase enzyme activity. Thus, our study provides that the new pyrazole derivative, LQFM219, demonstrated low toxicity, antinociceptive and anti-inflammatory potential in vitro and in vivo.pt_BR
dc.identifier.citationGALVÃO, Gustavo M. et al. Anti-inflammatory and antinociceptive activity profile of a new lead compound - LQFM289. International Immunopharmacology, Amsterdam, v. 88, e106893, 2020. DOI: 10.1016/j.intimp.2020.106893. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S1567576920323493?via%3Dihub. Acesso em: 28 jun. 2023.pt_BR
dc.identifier.doi10.1016/j.intimp.2020.106893
dc.identifier.issne- 1878-1705
dc.identifier.issn1567-5769
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S1567576920323493?via%3Dihub
dc.language.isoengpt_BR
dc.publisher.countryHolandapt_BR
dc.publisher.departmentInstituto de Química - IQ (RMG)pt_BR
dc.rightsAcesso Restritopt_BR
dc.titleAnti-inflammatory and antinociceptive activity profile of a new lead compound – LQFM219pt_BR
dc.typeArtigopt_BR

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