Analysis of cell proliferation and pattern of invasion in oral squamous cell carcinoma
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Data
2010
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Resumo
Cell proliferation markers play an
important role in the biological behavior of neoplasms.
This study investigated the immunohistochemical
expression of PCNA, Ki-67 and Cyclin B1 proteins
based on the pattern of cell invasion in oral squamous
cell carcinoma (OSCC). A total of 39 OSCC specimens
and 13 samples of normal oral mucosa (control) were
immunohistochemically analyzed. Protein expression
was evaluated according to World Health Organization
– Histological Malignancy Grading (WHO-HMG) and
a specific grading system for invasion, graded from 1
to 4, varying from a consistently well-defined “pushing”
border to diffuse infiltration and cellular dissociation,
and was then correlated with clinical features. We
found higher expression of Ki-67 and Cyclin B1 in
OSCC when compared with the control group. High
Ki-67 expression levels were more commonly seen in
the floor of the mouth than in the tongue (P = 0.009).
Cyclin B1 showed a positive correlation with histological
grade, according to WHO-HMG criteria (P = 0.01). Our
results suggest that Cyclin B1 is a reliable proliferation
marker for indicating degree of tumor proliferation. Correlations between PCNA, Ki-67, Cyclin B1 and
invasive tumor front with overall survival were not
observed. Further studies are needed in order to
elucidate whether cell proliferation activity at the
tumor invasion front is related to prognosis. (J Oral Sci
52, 417-424, 2010)
Descrição
Palavras-chave
PCNA, Cyclin B1, Pattern of invasion, Ki-67, Oral squamous cell carcinoma
Citação
WATANABE, Satiro et al. Analysis of cell proliferation and pattern of invasion in oral squamous cell carcinoma. Journal of Oral Science, Tokyo, v. 52, n. 3, p. 417-424, 2010.