Arctium lappa extract suppresses inflammation and inhibits melanoma progression
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Data
2019
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Resumo
Arctium lappa has been used as popular medicinal herb and health
supplement in Chinese societies. Bioactive components from A. lappa have attracted the attention of
researchers due to their promising therapeutic effects. In this study, we investigated the effects of
A. lappa hydroalcoholic extract (Alhe) during different models of inflammation, in vivo. Methods:
The anti-inflammatory activity was evaluated through the air pouch model. For this, mice received
an inflammatory stimulus with lipopolysaccharide (LPS) and were later injected with Alhe. To assess
anti-tumoral activity, the animals were inoculated with B16F10 cells and injected with Alhe every
5 days, along the course of 30 days. Controls were submitted to the same conditions and injected
with the vehicle. Peritoneal or air pouch fluids were collected to evaluate leukocyte counting or
cellular activation via quantification of cytokines and nitric oxide. Results: Alhe injection reduced
the neutrophil influx and production of inflammatory mediators in inflammatory foci after LPS
or tumor challenges. Furthermore, Alhe injection reduced tumor growth and enhanced mice
survival. Conclusions: Collectively, these data suggest that Alhe regulates immune cell migration
and activation, which correlates with favorable outcome in mouse models of acute inflammation and
melanoma progression.
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Arctium lappa, Natural product, Phytomedicine, Inflammation, Melanoma
Citação
NASCIMENTO, Bruno A. C. et al. Arctium lappa extract suppresses inflammation and inhibits melanoma progression. Medicines, Basel, v. 6, n. 3, e81, 2019. DOI: 10.3390/medicines6030081. Disponível em: https://www.mdpi.com/2305-6320/6/3/81. Acesso em: 29 jan. 2025.