Arctium lappa extract suppresses inflammation and inhibits melanoma progression

dc.creatorNascimento, Bruno A. C.
dc.creatorGardinassi, Luiz Gustavo Araujo
dc.creatorSilveira, Inaê M. G.
dc.creatorGallucci, Marília Ghiotti
dc.creatorTomé, Mariana A.
dc.creatorOliveira, Julia Fernanda Domingues de
dc.creatorMoreira, Mirella R. A.
dc.creatorMeirelles, Alyne Fávero Galvão
dc.creatorFaccioli, Lúcia Helena
dc.creatorSilva, Cristiane Tefé da
dc.date.accessioned2025-02-04T15:35:45Z
dc.date.available2025-02-04T15:35:45Z
dc.date.issued2019
dc.description.abstractArctium lappa has been used as popular medicinal herb and health supplement in Chinese societies. Bioactive components from A. lappa have attracted the attention of researchers due to their promising therapeutic effects. In this study, we investigated the effects of A. lappa hydroalcoholic extract (Alhe) during different models of inflammation, in vivo. Methods: The anti-inflammatory activity was evaluated through the air pouch model. For this, mice received an inflammatory stimulus with lipopolysaccharide (LPS) and were later injected with Alhe. To assess anti-tumoral activity, the animals were inoculated with B16F10 cells and injected with Alhe every 5 days, along the course of 30 days. Controls were submitted to the same conditions and injected with the vehicle. Peritoneal or air pouch fluids were collected to evaluate leukocyte counting or cellular activation via quantification of cytokines and nitric oxide. Results: Alhe injection reduced the neutrophil influx and production of inflammatory mediators in inflammatory foci after LPS or tumor challenges. Furthermore, Alhe injection reduced tumor growth and enhanced mice survival. Conclusions: Collectively, these data suggest that Alhe regulates immune cell migration and activation, which correlates with favorable outcome in mouse models of acute inflammation and melanoma progression.
dc.identifier.citationNASCIMENTO, Bruno A. C. et al. Arctium lappa extract suppresses inflammation and inhibits melanoma progression. Medicines, Basel, v. 6, n. 3, e81, 2019. DOI: 10.3390/medicines6030081. Disponível em: https://www.mdpi.com/2305-6320/6/3/81. Acesso em: 29 jan. 2025.
dc.identifier.doi10.3390/medicines6030081
dc.identifier.issne- 2305-6320
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/26520
dc.language.isoeng
dc.publisher.countrySuica
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RMG)
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectArctium lappa
dc.subjectNatural product
dc.subjectPhytomedicine
dc.subjectInflammation
dc.subjectMelanoma
dc.titleArctium lappa extract suppresses inflammation and inhibits melanoma progression
dc.typeArtigo

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