Quantitative imaging of magnetic nanoparticles in an unshielded environment using a large AC susceptibility array
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2022
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Background: Non-invasive magnetic imaging techniques are necessary to assist magnetic nanoparticles in biomedical
applications, mainly detecting their distribution inside the body. In Alternating Current Biosusceptometry (ACB),
the magnetic nanoparticle’s magnetization response under an oscillating magnetic field, which is applied through an
excitation coil, is detected with a balanced detection coil system.
Results: We built a Multi-Channel ACB system (MC-ACB) containing nineteen pick-up coils and obtained 2D quantitative
images of magnetic nanoparticle distributions by solving an inverse problem. We reconstructed the magnetic
nanoparticles spatial distributions in a field of view of 14 × 14 cm2
with a spatial resolution of 2.0 cm and sensitivity in
the milligram scale. A correlation coefficient between quantitative reconstructed and nominal magnetic nanoparticle
distributions above 0.6 was found for all measurements.
Conclusion: Besides other interesting features such as sufficient large field of view dimension for mice and rat studies,
portability, and the ability to assess the quantitative magnetic nanoparticles distributions in real-time, the MC-ACB
system is a promising tool for quantitative imaging of magnetic nanoparticles distributions in real-time, offering an
affordable setup for easy access in clinical or laboratory environments
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Magnetic nanoparticles, Inverse problem, Quantitative imaging, Alternate current biosusceptometry
Citação
SOARES, Guilherme et al. Quantitative imaging of magnetic nanoparticles in an unshielded environment using a large AC susceptibility array. Journal of Biological Engineering, San Francisco, v. 16, n. 5, p. 1-11, 2022. DOI: 10.1186/s13036-022-00305-9. Disponível em: file:///C:/Users/Usu%C3%A1rio/Downloads/s13036-022-00305-9.pdf. Acesso em: 11 abr. 2023.