The importance of understanding the distribution of GSTM1 and GSTT1 genotypes and haplotypes in a region with intense agriculture activity
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2019
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Brazil is one of the largest pesticide consumers in the world, mainly due to its intense agricultural activity. The
State of Goias, situated in Central Brazil, is a region recognized as an essential producer of soy, corn, beans,
sorghum, sugar cane, and cotton. In this study, we evaluated 602 unrelated individuals, distributed in central and
southern regions in Goias, presenting combined frequencies (haplotypes) of the GSTT1 and GSTM1 genes. In all
municipalities, the frequency of the GSTT1 null genotype was 38.2% and of the GSTM1 null genotype was 50.3%.
Goiania, the capital of Goias, presented the highest frequencies of GSTT1 and GSTM1 null genotypes, probably
due to a founder effect of non-representative colonizing ancestors. So, the ancestral population adapted to the
environment, with the frequencies observed in Goiania. However, nowadays, as there is excessive use of pesticides,
the community becomes susceptible to the harmful effects of xenobiotics exposure, mainly due to the high
frequency of GSTT1 and GSTM1 null genotypes. As in Goias, the consumption of pesticides has shown considerable
growth, haplotypes with null alleles are of high risk for the population. Our results indicated that it is
essential to understand the frequencies of the GSTT1 and GSTM1 genes for the monitoring of risk groups, like
farmers, who have contact with pesticides, directly or indirectly, as well as assisting in the development of
preventive medicine practices.
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Agricultural science, Environmental health, Environmental pollution, Frequencies, Environmental science, Haplotypes, Environmental toxicology, Exposure, Genetics, Population, Public health, Susceptible, Toxicology, Pesticides
Citação
ALVES, Alessandro Arruda; FRANCO, Fernanda Craveiro; GODOY, Fernanda Ribeiro; RAMOS, Jheneffer Sonara Aguiar; NUNES, Hugo Freire; SOARES, Thannya Nascimento; SILVA, Daniela de Melo e. The importance of understanding the distribution of GSTM1 and GSTT1 genotypes and haplotypes in a region with intense agriculture activity. Heliyon, London, v. 5, n. 2, e02815, 2019. DOI: 10.1016/j.heliyon.2019.e02815. eCollection 2019 Dec. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31872100/. Acesso em: 24 mar. 2023.