Evaluation of Haemophilus influenzae type b carrier status among children 10 years after the introduction of Hib vaccine in Brazil

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dc.creatorZanella, Rosemeire Cobo
dc.creatorBrandileone, Maria Cristina de Cunto
dc.creatorAndrade, Ana Lúcia
dc.creatorOgassavara, Cinthya Terumi
dc.creatorFiório, Cleiton Eduardo
dc.creatorBrandão, Angela Pires
dc.creatorAlmeida, Samanta Cristine Grassi
dc.creatorLemos, Ana Paula Silva
dc.creatorGorla, Maria Cecília
dc.creatorCarvalhanas, Telma Regina
dc.creatorSato, Helena
dc.creatorLiphaus, Bernadete
dc.creatorNerger, Maria Lígia
dc.creatorConde, Monica
dc.creatorRibeiro, Ana Freitas
dc.date.accessioned2018-05-28T14:20:19Z
dc.date.available2018-05-28T14:20:19Z
dc.date.issued2015
dc.description.abstractThe aim of the present study was to assess the prevalence of Haemophilus influenzae type b (Hib) nasopharyngeal (NP) colonisation among healthy children where Hib vaccination using a 3p+0 dosing schedule has been routinely administered for 10 years with sustained coverage (> 90%). NP swabs were collected from 2,558 children who had received the Hib vaccine, of whom 1,379 were 12-< 24 months (m) old and 1,179 were 48-< 60 m old. Hi strains were identified by molecular methods. Hi carriage prevalence was 45.1% (1,153/2,558) and the prevalence in the 12-< 24 m and 48-< 60 m age groups were 37.5% (517/1,379) and 53.9% (636/1,179), respectively. Hib was identified in 0.6% (16/2,558) of all children in the study, being 0.8% (11/1,379) and 0.4% (5/1,179) among the 12-< 24 m and 48-< 60 m age groups, respectively. The nonencapsulate Hi colonisation was 43% (n = 1,099) and was significantly more frequent at 48-< 60 m of age (51.6%, n = 608) compared with that at 12-< 24 m of age (35.6%, n = 491). The overall resistance rates to ampicillin and chloramphenicol were 16.5% and 3.7%, respectively; the co-resistance was detected in 2.6%. Our findings showed that the Hib carrier rate in healthy children under five years was very low after 10 years of the introduction of the Hib vaccine.pt_BR
dc.identifier.citationZANELLA, Rosemeire Cobo et al. Evaluation of Haemophilus influenzae type b carrier status among children 10 years after the introduction of Hib vaccine in Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 110, n. 6, p. 755-759, 2015.pt_BR
dc.identifier.issn0074-0276
dc.identifier.issne-1678-8060
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/15111
dc.language.isoporpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectBrazilpt_BR
dc.subjectHaemophilus influenzae type bpt_BR
dc.subjectNasopharyngeal carriagept_BR
dc.subjectHib conjugate vaccinept_BR
dc.titleEvaluation of Haemophilus influenzae type b carrier status among children 10 years after the introduction of Hib vaccine in Brazilpt_BR
dc.typeArtigopt_BR

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